Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic... (Publications)
BACKGROUND: For children below 6 years with suspected severe malaria attending a health care provider unable to provide parenteral malaria treatment, pre-referral rectal artesunate (RAS) is recommended [...] countries are in the process of rolling out quality-assured RAS for pre-referral treatment of severe malaria at community-level. The success of RAS depends, among other factors, on the acceptability of RAS [...] comprehensive multi-country observational research project Community Access to...
The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility (Publications)
Malaria persists at low levels on Zanzibar despite the use of vector control and case management. We use a metapopulation model to investigate the role of human mobility in malaria persistence on Zanzibar [...] parameterized using survey data on malaria prevalence, reactive case detection, and travel history. We find that in the absence of imported cases from mainland Tanzania, malaria would likely cease to persist [...] rapid diagnostic tests, a low rate of those infected with malaria seeking...
A review of malaria epidemiology and control in Papua New Guinea 1900 to 2021: progress made and future directions (Publications)
been four major periods of malaria control in PNG, with the current control programme having commenced in 2004. Each previous control programme was successful in reducing malaria burden in the country, but [...] al drivers of malaria transmission in PNG. Evaluations of historical control programs reveal poor planning and communication, and di culty in sustaining financial investment once malaria burden had decreased [...] The research and control of malaria has a long history in Papua New...
Accelerated development of malaria monoclonal antibodies (Publications)
healthy adults.(1) These promising results are the first of many to usher in a potential new era of malaria prevention.
Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions (Publications)
targeted reductions in malaria prevalence. METHODS: A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering [...] mathematical models of malaria dynamics coupled with machine learning. Our analysis identifies requirements of efficacy, coverage, and duration of effect for five novel malaria interventions to achieve [...] achieve specified health goals. RESULTS: We apply our approach to five malar...
Rethinking human resources and capacity building needs for malaria control and elimination in Africa (Publications)
considerable success in controlling malaria worldwide, progress toward achieving malaria elimination has largely stalled. In particular, strategies to overcome roadblocks in malaria control and elimination in Africa [...] Africa are critical to achieving worldwide malaria elimination goals—this continent carries 94% of the global malaria case burden. To identify key areas for targeted efforts, we combined a comprehensive [...] ve review of current literature with direct feedback gathered from...
Scalable process for high-yield production of PfCyRPA using insect cells for inclusion in a malaria virosome-based vaccine candidate (Publications)
been identified as a promising blood-stage candidate antigen to include in a broadly cross-reactive malaria vaccine. In the last couple of decades, substantial effort has been committed to the development [...] aiming to develop a scalable, high-yield, and high-quality PfCyRPA for inclusion in a virosome-based malaria vaccine candidate. Supplements with antioxidants improved PfCyRPA volumetric titers by 50% when added
Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria... (Publications)
artesunate (RAS) require urgent referral to a health facility where appropriate treatment for severe malaria can be provided. However, the rapid improvement of a child's condition after RAS administration may [...] completion is limited. METHODS: An observational study accompanied the roll-out of RAS in three malaria endemic settings in the Democratic Republic of the Congo (DRC), Nigeria and Uganda. Community health [...] health workers and primary health centres enrolled children under 5 years...
