The effect of mass mosquito trapping on malaria transmission and disease burden (SolarMal): a stepped-wedge cluster-randomised trial (Publications)
clinical malaria episodes were recorded in intervened clusters and 33 episodes in non-intervened clusters (adjusted effectiveness 40.8% [95% CI -172.8 to 87.1], p=0.5) during the roll-out. Malaria prevalence [...] unexpectedly low clinical incidence of malaria during roll-out led to an imprecise estimate of effectiveness from the clinical incidence data. The substantial effect on malaria prevalence is explained by reduction [...] mosquitoes indoors and outdoors. We assessed the effects of mass...
A crossover study to evaluate the diversion of malaria vectors in a community with incomplete coverage of spatial repellents in the Kilombero Valley,... (Publications)
BACKGROUND: Malaria elimination is unlikely to occur if vector control efforts focus entirely on transmission occurring indoors without addressing vectors that bite outdoors and outside sleeping hours [...] Kilombero, Tanzania. The density of resting and blood-engorged mosquitoes and human blood index (HBI) of malaria vector species per household was measured among 90 households using or not using 0.03 % transfluthrin [...] non-users. The repellent coils did not affect An. funestus densities or...
Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire (Publications)
Portable microscopy may facilitate quality diagnostic care in resource-constrained settings. We compared a handheld light microscope (Newton Nm1) with a mobile phone attachment to conventional light m
Pregnant women and infants as sentinel populations to monitor prevalence of malaria: results of pilot study in Lake Zone of Tanzania (Publications)
screened for malaria infection using a malaria rapid diagnostic test (RDT) from December 2012 to November 2013, regardless of symptoms. Participants who tested positive were treated for malaria per national [...] BACKGROUND: As malaria control interventions are scaled-up, rational approaches are needed for monitoring impact over time. One proposed approach includes monitoring the prevalence of malaria infection among [...] facility (HF) visits. This pilot explored the feasibility and utility of...
Mapping intra-urban malaria risk using high resolution satellite imagery: a case study of Dar es Salaam (Publications)
of malaria in rapidly growing African urban settlements. The complex and heterogeneous nature of urban malaria requires a better understanding of the spatial and temporal patterns of urban malaria risk [...] localized heterogeneity of malaria transmission and develop a high resolution predictive malaria risk map of Dar es Salaam. RESULTS: Results indicate that the risk of malaria infection varied across the [...] settlements by 2030, the burden of malaria among urban populations in Africa...
Hemolysis after oral artemisinin combination therapy for uncomplicated <em>Plasmodium falciparum</em> malaria (Publications)
weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment [...] occurs after oral artemisinin-based combination therapy. Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis [...] g/dL; p = 0.002). These findings indicate a need for increased...
Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models (Publications)
BACKGROUND: The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints [...] settings. Decisions about implementation will need to consider levels of malaria burden, the cost-effectiveness and coverage of other malaria interventions, health priorities, financing, and the capacity of the [...] iveness of routine use of the RTS,S/AS01 vaccine in African settings....
Susceptibility of <em>Anopheles gambiae</em> to insecticides used for malaria vector control in Rwanda (Publications)
a major threat to the gains made in malaria control. To monitor the presence and possible emergence of resistance against a variety of insecticides used for malaria control in Rwanda, nationwide insecticide [...] using the synergist PBO. CONCLUSION: This is the first nationwide study of insecticide resistance in malaria vectors in Rwanda. It shows the gradual increase of insecticide resistance to pyrethroids (lambd [...] testing and implement an insecticide resistance management strategy to...
Nouvelles approches pour la prévention de la malaria chez le voyageur (Publications)
Malaria is declining in many tropical countries. This reduction challenges our usual preventive strategies. In moderate to low risk areas, the Swiss guidelines recommend a stand-by emergency treatment [...] making through three clinical studies. The first showed that travelers visiting moderate to low risk malaria areas prefer a standby emergency treatment rather than chemoprophylaxis. The second study investigates
