Haemoglobin changes and risk of anaemia following treatment for uncomplicated falciparum malaria in sub-Saharan Africa (Publications)
BACKGROUND: Anaemia is common in malaria. It is important to quantitate the risk of anaemia and to distinguish factors related to the natural history of disease from potential drug toxicity. METHODS: [...] data analysis based on nine randomized controlled trials of treatments of uncomplicated falciparum malaria from 13 sub-Saharan African countries. Risk factors for reduced haemoglobin (Hb) concentrations and
Natural immune response to <em>Plasmodium vivax </em>alpha-helical coiled coil protein motifs and its association with the risk of <em>P. vivax</em>... (Publications)
selected coiled coil antigens might be good markers of both exposure and acquired immunity to P. vivax malaria, and further preclinical investigation should be performed to determine their potential as P. vivax
Controlled human malaria infection leads to long-lasting changes in innate and innate-like lymphocyte populations (Publications)
clinically silent. To overcome this limitation, we examined blood samples from a controlled human malaria infection (CHMI) study in a Tanzanian cohort, in which volunteers underwent CHMI with a low or high
Modelling the relationship between malaria prevalence as a measure of transmission and mortality across age groups (Publications)
prevalence has been used widely as a measure of malaria transmission, especially in malaria endemic areas. However, its contribution and relationship to malaria mortality across different age groups has not [...] all-cause and malaria-specific mortality. CONCLUSION: Malaria parasitaemia from cross-sectional surveys was associated with mortality across age groups over 4 to 5 year periods with clinical malaria more strongly [...] surveys from the Kisumu HDSS between 2007 and 2015 were used to...
Modelling reactive case detection strategies for interrupting transmission of <em>Plasmodium falciparum</em> malaria (Publications)
BACKGROUND: As areas move closer to malaria elimination, a combination of limited resources and increasing heterogeneity in case distribution and transmission favour a shift to targeted reactive interventions [...] strategies vary, and it is unclear which are most effective in achieving elimination. METHODS: OpenMalaria, an established individual-based stochastic model, was used to simulate RCD in a Zambia-like setting
Theory of reactive interventions in the elimination and control of malaria (Publications)
in maintaining the disease-free state after achieving malaria elimination (through other interventions). CONCLUSION: RCD alone can eliminate malaria in only a very limited range of settings, where transmission [...] BACKGROUND: Reactive case detection (RCD) is an integral part of many malaria control and elimination programmes and can be conceived of as a way of gradually decreasing transmission. However, it is unclear
Models of effectiveness of interventions against malaria transmitted by <em>Anopheles albimanus</em> (Publications)
BACKGROUND: Most impact prediction of malaria vector control interventions has been based on African vectors. Anopheles albimanus, the main vector in Central America and the Caribbean, has higher intrinsic [...] Hispaniola and intervention effect data from southern Mexico were used to parameterize mathematical malaria models. Indoor residual spraying (IRS), insecticide-treated nets (ITNs), and house-screening were [...] excito-repellency. It also supports the idea that housing improvements have...
Videographic analysis of flight behaviours of host-seeking <em>Anopheles arabiensis</em> towards BG-Malaria trap (Publications)
The BG-Malaria trap (BGM) is an adaptation of the well-known BG-Sentinel trap (BGS) with greater trapping efficiencies for anopheline and culicine mosquitoes. Its continued optimization requires greater
