Abietane-type diterpenoid amides with highly potent and selective activity against <em>Leishmania donovani</em> and <em>Trypanosoma cruzi</em> (Publications)
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabietyl amides by simple and facile methods, and their activities against two disease-causing trypanosom
Independent at heart: persistent association of altitude with ischaemic heart disease mortality after consideration of climate, topography and built... (Publications)
BACKGROUND: Living at higher altitude was dose-dependently associated with lower risk of ischaemic heart disease (IHD). Higher altitudes have different climatic, topographic and built environment prop
Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients (Publications)
OBJECTIVES: SQ109, an asymmetrical diamine, is a novel anti-TB drug candidate. This first study in patients was done to determine safety, tolerability, pharmacokinetics and bacteriological effect of d
Population genomics of <em>Mycobacterium tuberculosis</em> in Ethiopia contradicts the virgin soil hypothesis for human tuberculosis in sub-Saharan... (Publications)
Colonial medical reports claimed that tuberculosis (TB) was largely unknown in Africa prior to European contact, providing a "virgin soil" for spread of TB in highly susceptible populations previously
<em>IL-33</em> polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort (Publications)
BACKGROUND: IL-33 polymorphisms influence the susceptibility to asthma. IL-33 indirectly induces Th2-immune responses via dendritic cell activation, being important for development of atopic diseases.
Microbial contamination along the main open wastewater and storm water channel of Hanoi, Vietnam, and potential health risks for urban farmers (Publications)
The use of wastewater in agriculture and aquaculture has a long tradition throughout Asia. For example, in Hanoi, it creates important livelihood opportunities for > 500,000 farmers in peri-urban comm
Screening for pulmonary tuberculosis in Tanzanian prison and computer-aided interpretation of chest X-rays (Publications)
SETTING: Tanzania is a high-burden country for tuberculosis (TB), and prisoners are a high-risk group that should be screened actively, as recommended by the World Health Organization. Screening algor
Extrinsic skin ageing in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and... (Publications)
BACKGROUND: It has been suggested that extrinsic skin ageing manifests differently in Caucasians versus East Asians. In particular, from previous studies it was concluded that Caucasians are more pron
Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children (Publications)
OBJECTIVES: We evaluated the ability of the Xpert(R) MTB/RIF assay to detect Mycobacterium tuberculosis in whole blood of children with tuberculosis in tuberculosis endemic settings with high rates of