Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthe
The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of... (Publications)
BACKGROUND: In the Tanzanian city of Dar es Salaam, high coverage of long-lasting insecticidal nets (LLINs), larvicide application (LA) and mosquito-proofed housing, was complemented with improved acc
Negligible risk of inducing resistance in <em>Mycobacterium tuberculosis</em> with single-dose rifampicin as post-exposure prophylaxis for leprosy (Publications)
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among
Design of trials for interrupting the transmission of endemic pathogens (Publications)
BACKGROUND: Many interventions against infectious diseases have geographically diffuse effects. This leads to contamination between arms in cluster-randomized trials (CRTs). Pathogen elimination is th
The DASH study (2014-2017) [Video] (Publications)
The DASH study, or in full the Disease, Activity and Schoolchildren’s Health in Port Elizabeth, South Africa, is a joint research project between the University of Basel, Switzerland, the Swiss Tropic