hERG,<em> Plasmodium</em> life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole (Publications)
Toward addressing the cardiotoxicity liability associated with the antimalarial drug astemizole (AST, hERG IC50 = 0.0042 μM) and its derivatives, we designed and synthesized analogues based on compoun
A new model for ranking schools of public health: the public health academic ranking (Publications)
Objectives: As there is no ranking designed for schools of Public Health, the aim of this project was to create one. Methods: To design the Public Health Academic Ranking (PHAR), we used the InCites B
Phylogenetic analysis of pyruvate-ferredoxin oxidoreductase, a redox enzyme involved in the pharmacological activation of nitro-based prodrugs in... (Publications)
The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the
Child health and infection with low density (CHILD) malaria: a protocol for a randomised controlled trial to assess the long-term health and... (Publications)
INTRODUCTION: As malaria declines, low-density malaria infections (LMIs) represent an increasing proportion of infections and may have negative impacts on child health and cognition, necessitating dev
Concordance of targeted and whole genome sequencing for <em>Mycobacterium tuberculosis</em> genotypic drug susceptibility testing (Publications)
Targeted Next Generation Sequencing (tNGS) and Whole Genome Sequencing (WGS) are increasingly used for genotypic drug susceptibility testing (gDST) of Mycobacterium tuberculosis. Thirty-two multi-drug
Attributes of <em>Anopheles gambiae</em> swarms in South Central Uganda (Publications)
BACKGROUND: Anopheles gambiae continues to be widespread and an important malaria vector species complex in Uganda. New approaches to malaria vector control are being explored including population sup
Expression of the MSPDBL2 antigen in a discrete subset of <em>Plasmodium falciparum</em> schizonts is regulated by GDV1 but may not be linked to... (Publications)
The Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential
Validation of the emergency department-paediatric early warning score (ED-PEWS) for use in low- and middle-income countries: a multicentre... (Publications)
Early recognition of children at risk of serious illness is essential in preventing morbidity and mortality, particularly in low- and middle-income countries (LMICs). This study aimed to validate the
Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment (Publications)
BACKGROUND: Control efforts of soil-transmitted helminthiases rely primarily on large scale administration with anthelminthic drugs. The assessment of drug efficacies and understanding of drug behavio
