Development of non-linear models predicting daily fine particle concentrations using aerosol optical depth retrievals and ground-based measurements at... (Publications)
Epidemiological studies generally use particulate matter measurements with diameter less 2.5 μm (PM2.5) from monitoring networks. Satellite aerosol optical depth (AOD) data has considerable potential
Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey (Publications)
BACKGROUND: Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidenc
Hyperglycaemia is inversely correlated with live <em>M. bovis</em> BCG-specific CD4+ T cell responses in Tanzanian adults with latent or active... (Publications)
INTRODUCTION: The rising prevalence of Diabetes mellitus (DM) in high TB-endemic countries may adversely affect sustainability of TB control since DM constitutes a risk factor for development of activ
Physical activity and dual disease burden among South African primary schoolchildren from disadvantaged neighbourhoods (Publications)
People from low- and middle-income countries still face challenges stemming from parasitic infections. Additionally, non-communicable diseases (NCDs) and their risk factors are rapidly increasing, whi
<em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> infection dynamics: re-infections, recrudescences and relapses (Publications)
BACKGROUND: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort s
Development of dengue virus serotype-specific NS1 capture assays for the rapid and highly sensitive identification of the infecting serotype in human... (Publications)
Dengue fever can be caused by one of four distinct dengue virus (DENV) serotypes that cocirculate in many parts of the world. Point of care serotype-specific nonstructural protein-1 (NS1) capture assa
Combined approach of backbone amide linking and on-resin n-methylation for the synthesis of bioactive and metabolically stable peptides (Publications)
Rhabdopeptides are a large class of nonribosomal peptides from the bacteria Xenorhabdus and Photorhabdus with low micromolar activity against different protozoa, which are the causative agents of seve
Potent inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) featuring a spirocyclic scaffold (Publications)
With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhibitors of this key enzyme in the folate biosynthes