Estimating particulate exposure from modern municipal waste incinerators in Great Britain (Publications)
modeled PM10 concentrations were 1.00 x 10-5 to 5.53 x 10-2 mug m-3, a small contribution to ambient background levels which were typically 6.59-2.68 x 101 mug m-3, 3-5 orders of magnitude higher. While low
The exit interview as a proxy measure of malaria case management practice: sensitivity and specificity relative to direct observation (Publications)
trained research officer as part of a repeat cross sectional survey. Patient recall of 5 forms of clinical advice and 5 forms of clinical action were then assessed at service exit and statistical analyses [...] exit interviews with respect to clinical advice ranged from 36.2% to 96.4% and specificity from 53.5% to 98.6%. With respect to clinical actions, sensitivity of the exit interviews ranged from 83.9% to
Effect of fireworks events on urban background trace metal aerosol concentrations: is the cocktail worth the show? (Publications)
measured in city centre parkland increased local background PM(2.5) concentrations as follows: Sr (x86), K (x26), Ba (x11), Co (x9), Pb (x7), Cu (x5), Zn (x4), Bi (x4), Mg (x4), Rb (x4), Sb (x3), P (x3), Ga (x2) [...] We report on the effect of a major firework event on urban background atmospheric PM(2.5) chemistry, using 24-h data collected over 8 weeks at two sites in Girona, Spain. The firework pollution episode
Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modfied in the terminal groups (Publications)
derivatives with various 6-membered (7a-c) and 5-membered (7d-o) heterocyclic rings replacing the terminal pyridyl rings of the lead compound DB766{(2,5-bis[2-i-propoxy-4-(2-pyridylimino)aminophenylfuran]} [...] good activity versus T. cruzi, T. brucei rhodesiense and P. falciparum (IC50 = 200 nM, 32 nM and 8.5 nM, respectively). Three compounds (7g, 7i, 7j) with thiazole replacing the pyridine rings gave low
Metabolic profiling framework for discovery of candidate diagnostic markers of malaria (Publications)
metabolites (i) 4-amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]pyrimidin-2(1H)-one, (ii) 2-amino-4-({[5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-4,5-dihydrofuran-2-yl] methyl}sulfanyl)butanoic
Randomised trial of SPf66 vaccine against <em>Plasmodium falciparum</em> malaria in children in southern Tanzania (Publications)
each under-5 child suffers on average 3 clinical fever episodes per year. Minimum estimated community rates for serious malaria (cerebral malaria or malaria and anaemia) affect approximatively 5% of all children [...] conditions of a field experiment, the annual incidence of a febrile illness (axillary temperature > or = 37.5 degrees C) reported to the curative primary health services in each child was 0.86 of which 0,35 can
The exit interview as a proxy measure of malaria case management practice: sensitivity and specificity relative to direct observation (Publications)
trained research officer as part of a repeat cross sectional survey. Patient recall of 5 forms of clinical advice and 5 forms of clinical action were then assessed at service exit and statistical analyses [...] exit interviews with respect to clinical advice ranged from 36.2% to 96.4% and specificity from 53.5% to 98.6%. With respect to clinical actions, sensitivity of the exit interviews ranged from 83.9% to
A switch in regulatory T cells through farm-exposure during immune maturation in childhood (Publications)
BACKGROUND: Farm exposure protects against development of allergies early in life. At 4.5 years, protection against asthma by farm-milk exposure was partially mediated by regulatory T-cells (Tregs). The [...] effect via Tregs during childhood immune maturation. METHODS: Tregs were assessed longitudinally at 4.5 and 6 years in 111 children (56 farm, 55 reference children) from the PASTURE/EFRAIM birth cohort ( [...] Treg percentage before and after stimulation and FOXP3 mRNA-expression ex vivo...
Estimating particulate exposure from modern municipal waste incinerators in Great Britain (Publications)
modeled PM10 concentrations were 1.00 x 10-5 to 5.53 x 10-2 mug m-3, a small contribution to ambient background levels which were typically 6.59-2.68 x 101 mug m-3, 3-5 orders of magnitude higher. While low
Different strategies to overcome the effect of carbimazole on high- and low-dose radioiodine therapy: results from continuous dose-effect models (Publications)
and 128 Gy in toxic nodular goitre. The estimated radioiodine target dose amplification factor was 5.5 for Graves' disease and 3.0 for toxic nodular goitre. CONCLUSIONS: Simultaneous carbimazole reduces [...] Radioiodine target doses between 33 and 839 Gy were applied. Overall, the euthyroidism rates were 16.5% and 64.8%, while the hypothyroidism rates were 37.6% and 14.8% in Graves' disease and toxic nodular [...] goitre, respectively. The success rate with simultaneous carbimazole (median dose...