Evaluation of standard field and laboratory methods to compare protection times of the topical repellents PMD and DEET (Publications)
in the AIC test were 0.5, 2 and 2 hours against Ae. aegypti, An. stephensi and Cx. quinquefasciatus, respectively, and the corresponding median CPTs for PMD were 0.5, 1 and 0.5 hours. In conclusion, DEET
Cross-sectional serological survey for <em>Leptospira spp.</em> in beef and dairy cattle in two districts in Uganda (Publications)
9-24.5%). Pomona seroprevalence was highest with 9.45% (6.4-13.7%), followed by Kenya 5.09% (2.9-8.6%), Nigeria 4.00% (2.1-7.2%), Wolfii 3.27% (1.6-6.3%), Butembo 1.86% (0.7-4.4%), Hardjo 1.45% (0.5-3.9%)
Discordances in the application of different criteria for quantification of paediatric abdominal obesity: an analysis of two Swiss studies (Publications)
abdominal obesity varied between 3.1 and 49.4% in boys, and 4.7 and 55.5% in girls (Ballabeina), and between 1.8 and 36.3% in boys and 4.5 and 37.3% in girls (KISS). Among children considered as abdominally [...] 190 girls and 162 boys (Ballabeina), and from 134 girls and 113 boys (Kinder-Sportstudie, KISS) aged 5-11 years were used. TBF was assessed by bioimpedance (Ballabeina) or dual energy X-ray absorption (KISS)
Assessing health risk due to exposure to arsenic in drinking water in Hanam province, Vietnam (Publications)
tube-well water for drinking purpose were 25.3 × 10-5 (using only well water) and 7.6 × 10-5 (using both well and rain water). The skin cancer risk would be 11.5 times higher if the water was not filtered. I
Incidence and predictors of immune reconstitution inflammatory syndrome in a rural area of Mozambique (Publications)
patients developed IRIS [26.5%, incidence rate 3.1 cases/100 persons-month of ART (95% CI 2.2-4.3)]. Median time to IRIS onset was 62 days from ART initiation (IQR 35.5-93.5). Twenty-five cases (69.4%)
Effects of transportation noise and particulate matter on the cardiovascular system: what is the new evidence? (Publications)
increase in daily PM2.5 concentration. A comprehensive analysis of 12 European cohort studies addressing the long term effects found a 13% increased risk of coronary events per 5 mug/m3 increase in estimated [...] estimated annual mean PM2.5. Noise exposure triggers an increase in sympathetic responses (fight-flight reactions) and increased release of corticoids (defeat reactions). In 2018 the World Health Organization
New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: synthesis, <em>in vitro</em> and<em> in vivo</em> biological... (Publications)
of > 60 days upon a 4 × 5 mg/kg dose i. p. treatment. Moreover, thermal melting analysis measurement ΔT(m) for this series of diamidines/poly (dA-dT) complexes fell between 0.5 and 19 °C with 6c showing [...] amidines (6a-c, 13a,b and 17), their aza analogues (23 and 27) and respective methoxyamidine prodrugs (5, 7, 12a,b, 22 and 26). All diamidines were assessed in vitro against Trypanosoma brucei rhodesiense
The consequences of declining population access to insecticide-treated nets (ITNs) on net use patterns and physical degradation of nets after 22... (Publications)
77.5% of members slept under ITNs. In households without sufficient nets, pregnant women (54.6%), children < 5 years (45.8%) and adults (42.1%) were prioritized, with fewer school-age children 5-14 years [...] common among people residing in houses without sufficient nets for all age groups, apart from children < 5. Nets were less likely to be serviceable if: [Formula: see text] 3 people slept under them (OR 0.50 [...] CONCLUSION: Users determined the useful life of ITNs and prioritized...
Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection... (Publications)
(p/microL) (TBS and uRDT) compared to 5.6 p/microL (cRDT) based on TBS density measurements. TBS, uRDT and cRDT did not detect any of the 70/123 samples positive by qPCR below 5.86 p/microL, the qPCR density [...] in days (ranges) were 14.5 (10-20), 18.0 (15-28), 18.0 (15-20) and 18.0 (16-24) for qPCR, TBS, uRDT and cRDT, respectively; qPCR detected parasitaemia significantly earlier (3.5 days) than the other tests [...] 279 samples were collected from 24 participants; 123 were positive by...
Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)
METHODS: Ivermectin was incubated in the presence of recombinant human cytochrome P(450) 3A4/5 (CYP 3A4/5) to produce ivermectin metabolites. In total, nine metabolites were purified by semi-preparative [...] ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were predominantly formed by CYP3A4, whereas metabolite M9 (hydroxy-H(2)B(1a)) was mainly produced by CYP3A5. Both desmethyl-H(2)B(1a) (M1) [...] against An. stephensi at C(max) levels. Interestingly, half-lives of M1 (54.2...