Use of portable exposimeters to monitor radiofrequency electromagnetic field exposure in the everyday environment (Publications)
outdoor microenvironments from 20 different municipalities in Switzerland: 5 different city centers, 5 central residential areas, 5 non-central residential areas, 15 rural residential areas, 15 rural centers [...] months on the same paths. Results: Mean RF-EMF exposure (sum of 15 main frequency bands between 87.5 and 5,875 MHz) was 0.53 V/m in industrial zones, 0.47 V/m in city centers, 0.32 V/m in central residential
CD4 surveillance in Scotland: perspectives on severe HIV-related immunodeficiency (Publications)
count was higher in women (by 2.1; SE, 0.5), in injecting drug users (IDU; by 1.8; SE, 0.5) and in younger patients (by 1.5 per 10 years; SE, 0.2), but reduced by 1.5 (SE, 0.1) per calendar year of recruitment [...] patients in 1993-1994 with a first CD4 count of > or = 500 x 10(6)/l had seroconverted within the past 5 years. Two-thirds of non-IDU (67%; 348 out of 517) were already severely immunodeficient at or before
Validation of a rhinitis symptom questionnaire (ISAAC core questions) in a population of Swiss school children visiting the school health services (Publications)
most strongly associated with reported hay fever (OR = 5.7, 95% CI 4.4-7.4), nose problems accompanied by itchy-watery eyes (OR = 4.4, 95% CI: 3.3-5.7), symptoms occurring only during pollen season (March [...] (March through September) (OR = 4.9, 95% CI: 3.6-6.5) and a combination of these latter two symptoms (OR = 5.8, 95% CI: 4.1-8.1). The association was stronger for a sensitization to outdoor allergens than [...] than for indoor allergens. The specificity of the various questions was high,...
CD4 surveillance in Scotland: perspectives on severe HIV-related immunodeficiency (Publications)
count was higher in women (by 2.1; SE, 0.5), in injecting drug users (IDU; by 1.8; SE, 0.5) and in younger patients (by 1.5 per 10 years; SE, 0.2), but reduced by 1.5 (SE, 0.1) per calendar year of recruitment [...] patients in 1993-1994 with a first CD4 count of > or = 500 x 10(6)/l had seroconverted within the past 5 years. Two-thirds of non-IDU (67%; 348 out of 517) were already severely immunodeficient at or before
Validation of a rhinitis symptom questionnaire (ISAAC core questions) in a population of Swiss school children visiting the school health services (Publications)
most strongly associated with reported hay fever (OR = 5.7, 95% CI 4.4-7.4), nose problems accompanied by itchy-watery eyes (OR = 4.4, 95% CI: 3.3-5.7), symptoms occurring only during pollen season (March [...] (March through September) (OR = 4.9, 95% CI: 3.6-6.5) and a combination of these latter two symptoms (OR = 5.8, 95% CI: 4.1-8.1). The association was stronger for a sensitization to outdoor allergens than [...] than for indoor allergens. The specificity of the various questions was high,...
Use of portable exposimeters to monitor radiofrequency electromagnetic field exposure in the everyday environment (Publications)
outdoor microenvironments from 20 different municipalities in Switzerland: 5 different city centers, 5 central residential areas, 5 non-central residential areas, 15 rural residential areas, 15 rural centers [...] months on the same paths. Results: Mean RF-EMF exposure (sum of 15 main frequency bands between 87.5 and 5,875 MHz) was 0.53 V/m in industrial zones, 0.47 V/m in city centers, 0.32 V/m in central residential
Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection... (Publications)
(p/microL) (TBS and uRDT) compared to 5.6 p/microL (cRDT) based on TBS density measurements. TBS, uRDT and cRDT did not detect any of the 70/123 samples positive by qPCR below 5.86 p/microL, the qPCR density [...] in days (ranges) were 14.5 (10-20), 18.0 (15-28), 18.0 (15-20) and 18.0 (16-24) for qPCR, TBS, uRDT and cRDT, respectively; qPCR detected parasitaemia significantly earlier (3.5 days) than the other tests [...] 279 samples were collected from 24 participants; 123 were positive by...
Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)
METHODS: Ivermectin was incubated in the presence of recombinant human cytochrome P(450) 3A4/5 (CYP 3A4/5) to produce ivermectin metabolites. In total, nine metabolites were purified by semi-preparative [...] ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were predominantly formed by CYP3A4, whereas metabolite M9 (hydroxy-H(2)B(1a)) was mainly produced by CYP3A5. Both desmethyl-H(2)B(1a) (M1) [...] against An. stephensi at C(max) levels. Interestingly, half-lives of M1 (54.2...
The consequences of declining population access to insecticide-treated nets (ITNs) on net use patterns and physical degradation of nets after 22... (Publications)
77.5% of members slept under ITNs. In households without sufficient nets, pregnant women (54.6%), children < 5 years (45.8%) and adults (42.1%) were prioritized, with fewer school-age children 5-14 years [...] common among people residing in houses without sufficient nets for all age groups, apart from children < 5. Nets were less likely to be serviceable if: [Formula: see text] 3 people slept under them (OR 0.50 [...] CONCLUSION: Users determined the useful life of ITNs and prioritized...
Novel diamidines with activity against <em>Babesia divergens</em> <em>in vitro</em> and <em>Babesia microti in vivo</em> (Publications)
inhibitory concentration (IC(50)) of 1.5 ng/ml. In a murine model, several test compounds were effective enough to cure mice infected with Babesia microti at a dose of 12.5 and/or 25 mg/kg of body weight given
