Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study (Publications)
were not. Mean annual decline in FEV1 was -10.4 mL(95%CI -15.3, -5.5) per pack per day between assessments in men and -13.8 mL(95%CI-19.5,-8.1) in women. Decline per pack per day between 1991 and 2002 was
Socioeconomic disparities in childhood cancer survival in Switzerland (Publications)
nervous system (CNS) tumors); with an overall 5-year survival of 77% (95%CI 75-79%). Higher SES, particularly parents' education, was associated with a lower 5-year cumulative mortality. Results varied by [...] (parental education, living condition, area-based SES). Using Cox proportional hazards models, we analyzed 5-year cumulative mortality in all patients registered in the Swiss Childhood Cancer Registry diagnosed
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: antimicrobial evaluation and mechanistic insights (Publications)
(4c) and ferrocenyl (5b) hybrids were tested in vivo against the rodent Plasmodium berghei mouse model. Both compounds caused a reduction in parasitemia relative to the control, with 5c displaying superior [...] ium tuberculosis. The hybrids containing a more hydrophobic substituent had enhanced activity ( 62.5muM).
Alkanediamide-linked bisbenzamidines are promising antiparasitic agents (Publications)
compounds (5, 6, 11) were evaluated in vivo in mice infected with the drug-sensitive (Lab 110 EATRO and KETRI 2002) or drug-resistant (KETRI 2538 and KETRI 1992) clinical isolates of T. brucei. Compounds 5 and [...] strain (K1). The in vitro cytotoxicity was determined against rat myoblast cells (L6). Seven compounds (5, 6, 10, 11, 12, 14, 15) showed high potency against both strains of T. brucei and P. falciparum with
Tetanus immunisation in geriatric patients with accidental wounds: how much is needed? (Publications)
physicians' records and vaccination documents in 35.7% (5/14). Antitoxin titres > 0.15 IU/ ml were considered protective, giving a seroprevalence of 92.5%. Sensitivities and negative predictive values for tetanus [...] the single booster immunisation the median titre rose from 1.2 to 14.2 IU/ml, in group B from 0.9 to 5.3 IU/ml after the first, and to 9.6 IU/ml after the third tetanus toxoid dose (p
Epitope mapping and fine specificity of human T and B cell responses for novel candidate blood-stage malaria vaccine P27A (Publications)
presented anti-P27A with higher affinity than unexposed volunteers. Increasing the dose of GLA-SE from 2.5 to 5 μg in pre-exposed volunteers improved anti-P27A affinity and decreased the number of recognized epitopes [...] the humoral response in pre-exposed volunteers, particularly when immunized with P27A formulated with 5 μg GLA-SE.
Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children (Publications)
14 (6.0%) had culture-confirmed tuberculosis. The Xpert(R) MTB/RIF assay detected M. tuberculosis in 5/232 (2.2%) blood samples with 1 (0.4%) error reading and presumably 1 (0.4%) false-positive result. [...] assay in children with culture-confirmed (1/14) versus no tuberculosis (1/117) was 7.1% (95% CI, 1.3-31.5). Three of the five Xpert(R) MTB/RIF positive patients had negative cultures, but were classified as [...] against a composite reference standard (culture-confirmed, highly probable or...
Risk factors for helminth infections in a rural and a peri-urban setting of the Dongting Lake area, People's Republic of China (Publications)
prevalences of single infections of S. japonicum, A. lumbricoides, hookworm and T. trichiura were 6.5%, 5.5%, 3.0% and 0.8%, respectively; the majority of the infections were of light intensity. We found
Diagnostic accuracy and case management of clinical malaria in the primary health services of a rural area in south-eastern Tanzania (Publications)
of any density, 25.5% of all children attending the health services had malaria. This yielded a sensitivity of 70.4% (IC95% = 65.9-74.8%) and a specificity of 68.9% (IC95% = 66.2-71.5%). Accordingly, 30 [...] cases left with no antimalarial treatment. Among malaria-diagnosed patients, 10% were underdosed and 10.5% were overdosed. In this area, as in many African rural areas, the low diagnostic accuracy may imply
Risk factors for helminth infections in a rural and a peri-urban setting of the Dongting Lake area, People's Republic of China (Publications)
prevalences of single infections of S. japonicum, A. lumbricoides, hookworm and T. trichiura were 6.5%, 5.5%, 3.0% and 0.8%, respectively; the majority of the infections were of light intensity. We found
