Risk factors for helminth infections in a rural and a peri-urban setting of the Dongting Lake area, People's Republic of China (Publications)
prevalences of single infections of S. japonicum, A. lumbricoides, hookworm and T. trichiura were 6.5%, 5.5%, 3.0% and 0.8%, respectively; the majority of the infections were of light intensity. We found
Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
initial cross-sectional survey, 40.5% of individuals were recorded by microscopy as infected with P. falciparum, and by PCR 60.5%, with the maximum prevalence in children aged 5-10 years. PCR-RFLP typing of
Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children (Publications)
14 (6.0%) had culture-confirmed tuberculosis. The Xpert(R) MTB/RIF assay detected M. tuberculosis in 5/232 (2.2%) blood samples with 1 (0.4%) error reading and presumably 1 (0.4%) false-positive result. [...] assay in children with culture-confirmed (1/14) versus no tuberculosis (1/117) was 7.1% (95% CI, 1.3-31.5). Three of the five Xpert(R) MTB/RIF positive patients had negative cultures, but were classified as [...] against a composite reference standard (culture-confirmed, highly probable or...
Diagnostic accuracy and case management of clinical malaria in the primary health services of a rural area in south-eastern Tanzania (Publications)
of any density, 25.5% of all children attending the health services had malaria. This yielded a sensitivity of 70.4% (IC95% = 65.9-74.8%) and a specificity of 68.9% (IC95% = 66.2-71.5%). Accordingly, 30 [...] cases left with no antimalarial treatment. Among malaria-diagnosed patients, 10% were underdosed and 10.5% were overdosed. In this area, as in many African rural areas, the low diagnostic accuracy may imply
Socioeconomic disparities in childhood cancer survival in Switzerland (Publications)
nervous system (CNS) tumors); with an overall 5-year survival of 77% (95%CI 75-79%). Higher SES, particularly parents' education, was associated with a lower 5-year cumulative mortality. Results varied by [...] (parental education, living condition, area-based SES). Using Cox proportional hazards models, we analyzed 5-year cumulative mortality in all patients registered in the Swiss Childhood Cancer Registry diagnosed
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: antimicrobial evaluation and mechanistic insights (Publications)
(4c) and ferrocenyl (5b) hybrids were tested in vivo against the rodent Plasmodium berghei mouse model. Both compounds caused a reduction in parasitemia relative to the control, with 5c displaying superior [...] ium tuberculosis. The hybrids containing a more hydrophobic substituent had enhanced activity ( 62.5muM).
Tetanus immunisation in geriatric patients with accidental wounds: how much is needed? (Publications)
physicians' records and vaccination documents in 35.7% (5/14). Antitoxin titres > 0.15 IU/ ml were considered protective, giving a seroprevalence of 92.5%. Sensitivities and negative predictive values for tetanus [...] the single booster immunisation the median titre rose from 1.2 to 14.2 IU/ml, in group B from 0.9 to 5.3 IU/ml after the first, and to 9.6 IU/ml after the third tetanus toxoid dose (p
Potential impact of climate change on schistosomiasis: a global assessment attempt (Publications)
CMIPs are designed to improve the workings of the GCMs. We chose RCP4.5 which represented a medium GHG emission increase and CMIP5, the most recently completed CMIP phase. Combining this meteorological [...] Panel on Climate Change (IPCC) predicts that global, average temperatures will increase by at least 1.5 degrees C in the near future and more by the end of the century if greenhouse gases (GHGs) emissions
Alkanediamide-linked bisbenzamidines are promising antiparasitic agents (Publications)
compounds (5, 6, 11) were evaluated in vivo in mice infected with the drug-sensitive (Lab 110 EATRO and KETRI 2002) or drug-resistant (KETRI 2538 and KETRI 1992) clinical isolates of T. brucei. Compounds 5 and [...] strain (K1). The in vitro cytotoxicity was determined against rat myoblast cells (L6). Seven compounds (5, 6, 10, 11, 12, 14, 15) showed high potency against both strains of T. brucei and P. falciparum with
Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project (Publications)
correlation between concentrations of PM metrics and NO2. LUR models have been developed for NO2, PM2.5 absorbance and Copper (Cu) in PM10 based on 20 sites in each of the 20 study areas of the ESCAPE project [...] concentrations with measured NO2 concentrations at the 20 additional NO2 sites in each area. For NO2, PM2.5 absorbance and PM10 Cu, the median LOOCV R2s were 0.83, 0.81 and 0.76 whereas the median HEV R2 were [...] were 0.52, 0.44 and 0.40. There was a positive association between the...