Resttaschentiefe nach parodontaler Regenerationstherapie: klinische Relevanz und Interpretation von Meta-Analyse-Daten (Publications)
remaining periodontal pockets of more than 3 respectively 5 mm after active therapy. The probability of remaining periodontal pockets over 3 respectively 5 mm was significantly higher after periodontal flap procedure [...] with GTR on average 57% and with the use of enamel maxtrix derivatives 74%. Using the cut-off value of 5 mm this probability was reduced to 8 and 17%, respectively. A new clinical attachment that was less
Data integration for the assessment of population exposure to ambient air pollution for global burden of disease assessment (Publications)
ambient PM2.5 levels exceeded the World Health Organization 10 mug/m3 (annual average) Guideline; 58% resided in areas above the 35 mug/m3 Interim Target-1. Global population-weighted PM2.5 concentrations [...] estimates. A Bayesian Hierarchical Model was developed to estimate annual average fine particle (PM2.5) concentrations at 0.1 degrees x 0.1 degrees spatial resolution globally for 2010-2016. The model i
Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2 (Publications)
examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and > 14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) [...] and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined
Low prevalence of bovine tuberculosis in Somali pastoral livestock, southeast Ethiopia (Publications)
7.0-14.0%), and 1.9 (95% CI, 0.9-4.0%), respectively, whereby camels had an odds ratio of 16.5 (95% CI, 5.0-55.0) when compared to cattle. There was no significant difference between livestock species [...] model for each species. The individual animal prevalence was 2.0% [95% confidence interval (CI), 0.5-8.4], 0.4% (95% CI, 0.1-3%), and 0.2% (95% CI, 0.03-1.3) in cattle, camels, and goats, respectively
Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression (Publications)
logistic regression. Results: This study included 304 participants with a median time on ART of 3.5 years (IQR = 1.7-5.3 years); 91% were on an NNRTI-based regimen and 9% were on a boosted PI-based regimen. Viral [...] successfully genotyped and 17/21 (81%) harboured > /=1 clinically relevant HIV-DRM. Of these, 13/17 (76.5%) had HIV-1 plasma viral loads of > 1000 copies/mL. CD4 cell count 8-fold increased odds of developing
A standardised method for interpreting the association between mutations and phenotypic drug resistance in <em>Mycobacterium tuberculosis</em> (Publications)
(93.1-95.5%), respectively. For second-line drugs, sensitivity varied from 67.4% (64.1-70.6%) for capreomycin to 88.2% (85.1-90.9%) for moxifloxacin, with specificity ranging from 90.0% (87.1-92.5%) for [...] moxifloxacin to 99.5% (99.0-99.8%) for amikacin.This study provides a standardised and comprehensive approach for the interpretation of mutations as predictors of M. tuberculosis drug-resistant phenotypes
Seroprevalence of varicella-zoster virus immunoglobulin G antibodies in Swiss adolescents and risk factor analysis for seronegativity (Publications)
as measured by ELISA was 95.5% (95% confidence interval, 94.5 to 96.4). When serum specimens that were indeterminate by ELISA were tested by FAMA, seroprevalence was 96.5% (95% confidence interval, 95
Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate (Publications)
was performed through a Phenomenex C8(2) analytical column (50.0mmx2.0mm, 5mum) with a mobile phase of acetonitrile (buffer B) and 5mM ammonium formate (buffer A) at a flow-rate of 0.3mL/min and a gradient [...] (deprotonated parent compound, M-). The validated linear dynamic range was between 156.25ng/mL and 5mug/mL and the achieved correlation coefficient (r(2)) was greater than 0.99. The validation results
Seroprevalence of Rift Valley fever, Q fever, and brucellosis in ruminants on the southeastern shore of Lake Chad (Publications)
and 10.8% (95% CI 3.0-18.5) in sheep. For brucellosis and Q fever, only cattle samples from islands were analyzed. For Q fever, the apparent seroprevalence was 7.8% (95% CI 5.6-10.1). For brucellosis, [...] the RBT showed a prevalence of 5.7% (95% CI 3.8-7.6), and ELISA showed 11.9% (95% CI 9.3-14.6) with a kappa value of 0.53 showing a moderate agreement between the two tests. This study confirms the presence
Seroprevalence survey of brucellosis among rural people in Mongolia (Publications)
were being older than 45 years (adjusted odds ratio [AOR] = 6.9, 95% CI = 5.1-8.7) and being a veterinarian (AOR = 2.8, 95% CI = 1.5-5.0). CONCLUSION: Our study confirms that human brucellosis seroprevalence