Heart rate variability and sleep-related breathing disorders in the general population (Publications)
population of young and healthy adults. Participants aged 25 to 41 years with a body mass index /=5 or an ODI > /=5. Multivariable regression models were constructed to assess the relation of HRV with either [...] AHI or ODI. Median age of the 1,255 participants was 37 years, 47% were men, and 9.6% had an AHI > /=5. Linear inverse associations of SDNN across AHI and ODI groups were found (p for trend = 0.006 and 0
Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression (Publications)
logistic regression. Results: This study included 304 participants with a median time on ART of 3.5 years (IQR = 1.7-5.3 years); 91% were on an NNRTI-based regimen and 9% were on a boosted PI-based regimen. Viral [...] successfully genotyped and 17/21 (81%) harboured > /=1 clinically relevant HIV-DRM. Of these, 13/17 (76.5%) had HIV-1 plasma viral loads of > 1000 copies/mL. CD4 cell count 8-fold increased odds of developing
Resttaschentiefe nach parodontaler Regenerationstherapie: klinische Relevanz und Interpretation von Meta-Analyse-Daten (Publications)
remaining periodontal pockets of more than 3 respectively 5 mm after active therapy. The probability of remaining periodontal pockets over 3 respectively 5 mm was significantly higher after periodontal flap procedure [...] with GTR on average 57% and with the use of enamel maxtrix derivatives 74%. Using the cut-off value of 5 mm this probability was reduced to 8 and 17%, respectively. A new clinical attachment that was less
Resource utilization and hospital cost of HIV/AIDS care in Italy in the era of highly active antiretroviral therapy (Publications)
proportion of patients receiving HAART in the third and fourth group increased from 37.1% to 56.5% and from 15.3% to 31.5%. The number of hospital days observed in this study was much lower than previously published [...] costs (L = Italian Lire, 1997 exchange rate US$ 1 = 1,704 Italian Lire) were L.23,725,584 (US$ 13,923.5), L.15,208,287 (US$ 8,925.1), L.11,942,761 (US$ 7,008.7) and L.7,660,942 (US$ 4,495.9) for the four
Macyranones: structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome (Publications)
the yeast 20S proteasome with an IC50 of 5.9 nM and the human constitutive proteasome and immunoproteasome with IC50 values of 21 and 15 nM, respectively. The beta5 subunit of the 20S proteasome was characterized [...] presence of the methylmalonamide residue facilitates the stabilization of macyranone A with the active beta5 subunit of the proteasome. Macyranone A exhibits a potent inhibitory effect against the parasites T
Financially incentivized knowledge assessments to improve provider compliance with treatment guidelines: a cluster-randomized controlled trial (Publications)
BACKGROUND: Despite increasing access to health care, under-5 mortality remains high in many parts of Sub-Saharan Africa. Interventions to improve quality of care have mostly focused on additional training [...] chosen for this study. All health care workers providing outpatient services to children under age 5 in these facilities will be included in the study. Facilities were randomized with equal probability [...] financing to health care worker performance on knowledge assessments can...
<em>Ascaris lumbricoides</em> and <em>Trichuris trichiura</em> infections associated with wastewater and human excreta use in agriculture in Vietnam (Publications)
Cryptosporidium parvum 5% and Cyclospora cayetanensis 1%). People having close contact with polluted Nhue River water had a higher risk of helminth infections (odds ratio [OR]=1.5, 95% confidence interval [...] human excreta for application in the field had an increased risk for a T. trichiura infection (OR=1.5, 95% CI 1.0-2.3). In contrast, tap water use in households was a protective factor against any helminth [...] had generally lower prevalences (OR=0.8, 95% CI 0.6-1.0), participants...
Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample,... (Publications)
linearity, stability, recovery, and haematocrit influence with a limit of quantification of 0.5 and 2.5 ng/mL, for venous and capillary blood respectively. Moxidectin was stable up to 2 months at storage [...] filtration for blood and plasma. Moxidectin was detected by multiple reaction monitoring (640.4 --> 528.5 m/z) using a Luna C8(2) (30 x 2.0 mm, 3 microm particle size, 100 A) analytical column with a gradient [...] identical time to reach maximal concentration of 4.0 h and a similar...
Performance of antigen detection for HRP2-based malaria rapid diagnostic tests in community surveys: Tanzania, July-November 2017 (Publications)
lower LOD at the 95% probability of positive RDT (4.3 ng/mL; 95% CI 3.4-5.4) when compared to pLDH/HRP2 dual target tests (5.4 ng/mL; 4.5-6.3), though this difference was not significant. With the exception [...] all other 14 villages (93.3%) showed RDT LOD estimates at 90% probability of positive RDT between 0.5 and 12.0 ng/mL. CONCLUSIONS: Both HRP2-only and pLDH/HRP2 combo RDTs utilized in a 2017 Tanzania cr
Pesticide exposure and cortical brain activation among farmworkers in Costa Rica (Publications)
bilateral reduced activation in the dorsolateral prefrontal cortices (beta = -3.1; 95% CI: -5.0, -1.2 and -2.3; 95% CI: -4.5, -0.2 per two-fold increase in 3-PBA for left and right cortices, respectively). These [...] metabolites or parent compounds in urine samples collected during two study visits (approximately 3-5 weeks apart). We assessed cortical brain activation in the prefrontal cortex during tasks of working [...] associated with reduced activation in the prefrontal cortex during a...