Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2 (Publications)
examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and > 14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) [...] and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined
Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate (Publications)
was performed through a Phenomenex C8(2) analytical column (50.0mmx2.0mm, 5mum) with a mobile phase of acetonitrile (buffer B) and 5mM ammonium formate (buffer A) at a flow-rate of 0.3mL/min and a gradient [...] (deprotonated parent compound, M-). The validated linear dynamic range was between 156.25ng/mL and 5mug/mL and the achieved correlation coefficient (r(2)) was greater than 0.99. The validation results
Seroprevalence of varicella-zoster virus immunoglobulin G antibodies in Swiss adolescents and risk factor analysis for seronegativity (Publications)
as measured by ELISA was 95.5% (95% confidence interval, 94.5 to 96.4). When serum specimens that were indeterminate by ELISA were tested by FAMA, seroprevalence was 96.5% (95% confidence interval, 95
Low prevalence of bovine tuberculosis in Somali pastoral livestock, southeast Ethiopia (Publications)
7.0-14.0%), and 1.9 (95% CI, 0.9-4.0%), respectively, whereby camels had an odds ratio of 16.5 (95% CI, 5.0-55.0) when compared to cattle. There was no significant difference between livestock species [...] model for each species. The individual animal prevalence was 2.0% [95% confidence interval (CI), 0.5-8.4], 0.4% (95% CI, 0.1-3%), and 0.2% (95% CI, 0.03-1.3) in cattle, camels, and goats, respectively
Recombinant expression of trypanosome surface glycoproteins in <em>Pichia pastoris</em> for the diagnosis of <em>Trypanosoma evansi</em> infection (Publications)
Pichia (P.) pastoris. The M5 strain of this yeast has an engineered N-glycosylation pathway resulting in homogenous Man5GlcNAc2 N-glycosylation which resembles the predominant Man9-5GlcNAc2 oligomannose structures
Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the Congolese liana <em>Ancistrocladus ileboensis</em> with potent... (Publications)
Dioncophylline F (1), the first 5,8'-coupled dioncophyllaceous alkaloid (i.e., lacking an oxygen function at C-6 and possessing an R-configuration at C-3), was isolated from the recently described Congolese [...] semistable and, thus, slowly interconverting atropo-diastereomers, whereas dioncophylline C2 (2), with its 5,1'-linkage, is configurationally stable at the axis. Eight further known naphthylisoquinolines were [...] isolated from A. ileboensis, among them dioncophylline A (P-10), its...
Low prevalence of bovine tuberculosis in Somali pastoral livestock, southeast Ethiopia (Publications)
7.0-14.0%), and 1.9 (95% CI, 0.9-4.0%), respectively, whereby camels had an odds ratio of 16.5 (95% CI, 5.0-55.0) when compared to cattle. There was no significant difference between livestock species [...] model for each species. The individual animal prevalence was 2.0% [95% confidence interval (CI), 0.5-8.4], 0.4% (95% CI, 0.1-3%), and 0.2% (95% CI, 0.03-1.3) in cattle, camels, and goats, respectively
Seroprevalence of Rift Valley fever, Q fever, and brucellosis in ruminants on the southeastern shore of Lake Chad (Publications)
and 10.8% (95% CI 3.0-18.5) in sheep. For brucellosis and Q fever, only cattle samples from islands were analyzed. For Q fever, the apparent seroprevalence was 7.8% (95% CI 5.6-10.1). For brucellosis, [...] the RBT showed a prevalence of 5.7% (95% CI 3.8-7.6), and ELISA showed 11.9% (95% CI 9.3-14.6) with a kappa value of 0.53 showing a moderate agreement between the two tests. This study confirms the presence
Heart rate variability and sleep-related breathing disorders in the general population (Publications)
population of young and healthy adults. Participants aged 25 to 41 years with a body mass index /=5 or an ODI > /=5. Multivariable regression models were constructed to assess the relation of HRV with either [...] AHI or ODI. Median age of the 1,255 participants was 37 years, 47% were men, and 9.6% had an AHI > /=5. Linear inverse associations of SDNN across AHI and ODI groups were found (p for trend = 0.006 and 0
Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of <em>Schistosoma mansoni</em> before and after treatment with... (Publications)
area in Cjte d'Ivoire highly endemic for S. mansoni. Stool specimens were collected over 5 consecutive days, and 5 egg-counts were made in each specimen by the Kato-Katz technique. The point prevalence of [...] of the first sample was 42.7% and the cumulative prevalence after the maximum sampling effort was 88.5%. Using generalized linear mixed models we found that the presence of S. mansoni eggs in a stool sample
