One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (Publications)
developed in the derivation cohort to the validation cohort, 50.5% of patients could be classified as "rule-out", 19% as "rule-in", 30.5% as "observe ". In the validation cohort the negative predictive [...] positive predictive value (PPV) for acute myocardial infarction in the "rule-in" zone was 75.6% (95%CI, 68.5-81.8%), respectively. NPV of the 1h-algorithm was higher compared to the classical dichotomous inte
Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants (Publications)
and to have reported respiratory symptoms in the first assessment. Average weight had increased by 5.5 kg in 11 years and 28% of smokers in 1991 had quit by the time of the reassessment [...] 8047 individuals (86% of alive persons), 6 528 individuals (70%) agreed to the health examination and 5 973 subjects (62%) completed the entire protocol. Non-participants in the reassessment were on average
Pacing pattern and speed skating performance in competitive long-distance events (Publications)
in lap times were significant in each instance for women's 3,000 m (p < 0.001). For the 5,000 m races, laps 5-12 in women and laps 8-12 in men were slower compared with previous laps (p < 0.001, for both [...] complete World Cup series. Elite skaters competed in long-distance races of different length (3,000, 5,000, and 10,000 m) and location (low/high altitude) where distribution of lap times were analyzed.
Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study (Publications)
assessments of serum immunoglobulin E antibodies (year 1, 4.5, 6), atopic dermatitis, wheezing symptoms, and asthma (year 1, 1.5, 2, 3, 4, 5, 6). RESULTS: At 6 years of age, 66% and 82% of the original
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 10. Effect of insecticide-treated bed nets on the dynamics of multiple... (Publications)
Plasmodium falciparum merozoite surface protein 2 (msp2) gene were studied in 120 children aged 5 months to 2.5 years, in a randomized controlled trial of insecticide-treated bed nets (ITNs) in Kiberege village [...] polymerase chain reaction-restriction fragment length polymorphism analysis in any one sample of 0.5 microL of packed peripheral blood cells. In children less than 18 months old this sensitivity was 61%
Estimating population and livestock density of mobile pastoralists and sedentary settlements in the south-eastern Lake Chad area (Publications)
were estimated to live in sedentary villages. In the mobile communities, we found 5.9 people per km2 at the beginning and 17.5 people per km2 at the end of the dry season. We recorded per km2 on average 21 [...] 21.0 cattle and 31.6 small ruminants in the sedentary villages and 66.1 cattle and 102.5 small ruminants in the mobile communities, which amounts to a mean of 86.6 tropical livestock units during the dry
Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants (Publications)
and to have reported respiratory symptoms in the first assessment. Average weight had increased by 5.5 kg in 11 years and 28% of smokers in 1991 had quit by the time of the reassessment [...] 8047 individuals (86% of alive persons), 6 528 individuals (70%) agreed to the health examination and 5 973 subjects (62%) completed the entire protocol. Non-participants in the reassessment were on average
One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (Publications)
developed in the derivation cohort to the validation cohort, 50.5% of patients could be classified as "rule-out", 19% as "rule-in", 30.5% as "observe ". In the validation cohort the negative predictive [...] positive predictive value (PPV) for acute myocardial infarction in the "rule-in" zone was 75.6% (95%CI, 68.5-81.8%), respectively. NPV of the 1h-algorithm was higher compared to the classical dichotomous inte
Alkamides from <em>Anacyclus pyrethrum</em> L. and their <em>in vitro</em> antiprotozoal activity (Publications)
isolated as an inseparable mixture (1:4). Compounds 3, 4, and 5 were isolated from Anacycluspyrethrum L. for the first time. While compounds 4 and 5 were previously known from the genus Achillea, compound 3 [...] deca-2E,4E-dienoic acid 2-phenylethylamide (4), undeca-2E,4E-dien-8,10-diynoic acid isopentylamide (5), tetradeca-2E,4E,12Z-trien-8,10-diynoic acid isobutylamide (6), and dodeca-2E,4E-dien acid 4-hydro
Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration (Publications)
challenge in eliminating schistosomiasis. Current approaches to identify hotspots require evaluation 2-5 y after a baseline survey and subsequent mass drug administration. Here, we develop statistical models [...] predicts whether Schistosoma mansoni infection prevalence will exceed the WHO threshold of 10% in year 5 ("prevalence hotspot") with 86% sensitivity, 74% specificity, and 93% negative predictive value (NPV; [...] whether S. mansoni moderate and heavy infection prevalence will exceed a...