Prospective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV... (Publications)
specificity estimates varied between sites, ranging from 26·5% (95% CI: 17·4%-38·0%) to 73·2% (60·4%-83·0%), and 75·0 (65·0%-82·9%) to 96·5 (92·1%-98·5%), respectively. Post-hoc exploratory analysis identified
Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads (Publications)
schistosomiasis and demonstrate the importance of finding the right balance among potency (e.g., EC50 < 5 and 0.5 μM), cell permeability (e.g., Papp > 2 × 106 cm/s) and kinetic aqueous solubility (e.g., > 10 μM) [...] (PZQ), previous and currently used oral anti-schistosomal drugs, possess lower cLogD7.4 values (≤2.5). Furthermore, the lipophilicity associated with PZQ corresponds to a highly permeable and sparingly
Safety and immunogenicity of radiation-attenuated PfSPZ vaccine in equatoguinean infants, children, and adults (Publications)
ed Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment [...] intervals in a randomized, double-blind, placebo-controlled trial stratified by age (6-11 months and 1-5, 6-10, 11-17, 18-35, and 36-61 years). All doses were successfully administered. In all, 192/207 injections [...] occurred in 67/69 vaccinees (97%) and 0/15 controls. Median...
Reproducibility of oscillometrically measured arterial stiffness indices: results of the SAPALDIA 3 cohort study (Publications)
variance was accounted for by the subject, 5.2%/8.1%/ < 0.01% by the fieldworker, 6.7%/7.8%/28.5% by variation between measurement days, and 19.4%/4%/16.5% by measurement error. Bland-Altman plots showed
Modelling the health and economic impacts of the elimination of river blindness (onchocerciasis) in Africa (Publications)
$37.2 million-$39.9 million and out-of-pocket payments by $25.5 million-$26.9 million over 2013-2045, and generate economic benefits up to $5.9 billion-$6.4 billion in terms of income gains. DISCUSSION: [...] terms of income gains. RESULTS: The elimination of onchocerciasis in Africa would avert 4.3 million-5.6 million disability-adjusted life years over 2013-2045 when compared with staying in the control mode
The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis (Publications)
NO2, the risk of having an exacerbation that same day increased significantly by 4.5% (95%CI:0.9-8.3) and 3.2% (95%CI:0.7-5.8) respectively. The overall increase in risk of exacerbation for a 10 mug/m(3) [...] mug/m(3) increase in air pollutant concentration was 11.2% (95%CI:6.0-16.8) for PM10 and 4.7% (95%CI:0.1-9.5) for NO2 Subanalysis showed significant higher relative risks during spring (PM10 1.198, 95%CI 1.102-1
Effect of insecticide-treated bed nets on the dynamics of multiple <em>Plasmodium falciparum</em> infections (Publications)
Plasmodium falciparum merozoite surface protein 2 (msp2) gene were studied in 120 children aged 5 months to 2.5 years, in a randomized controlled trial of insecticide-treated bed nets (ITNs) in Kiberege village [...] polymerase chain reaction-restriction fragment length polymorphism analysis in any one sample of 0.5 microL of packed peripheral blood cells. In children less than 18 months old this sensitivity was 61%
SCORE operational research on moving toward interruption of schistosomiasis transmission (Publications)
SCORE developed and funded the T5 strategy implemented in Egypt, Kenya, and Tanzania. It is likely that focal MDA campaigns, along with more targeted approaches, including a T5 strategy and snail control, [...] to elimination included a feasibility and acceptability assessment of test-treat-track-test-treat (T5) strategies and mathematical modeling. Future evaluations of interventions to eliminate schistosomiasis
Efficacy and safety of moxidectin, synriam, synriam-praziquantel <em>versus</em> praziquantel against <em>Schistosoma haematobium</em> and <em>S.... (Publications)
the other hand, Synriam plus praziquantel and praziquantel yielded CRs of 60.0% and 38.5% and ERRs of 96.0% and 93.5%, respectively. CRs observed in the treatment of S. mansoni were 13.0%, 6.7%, 27.0%, and [...] Synriam, Synriam plus praziquantel and praziquantel, respectively. ERRs ranged from 64.9% (Synriam) to 87.5% (praziquantel). CONCLUSION/SIGNIFICANCE: Synriam and moxidectin show low efficacy against S. haematobium
Association of ambient air pollution with lengths of hospital stay for Hanoi children with acute lower-respiratory infection, 2007-2016 (Publications)
was associated with a 5% (95%CI: 2%-8%) decrease in the odds of discharge from hospital among children with ALRI. Results were similar for PM10, but only for children aged 2-5 years. For the other pollutants [...] AND METHODS: The association was examined using admission data for 75,432 children in Hanoi, aged 0-5 years, hospitalized with acute lower-respiratory infection (ALRI) and daily air pollutant levels in