Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads (Publications)
schistosomiasis and demonstrate the importance of finding the right balance among potency (e.g., EC50 < 5 and 0.5 μM), cell permeability (e.g., Papp > 2 × 106 cm/s) and kinetic aqueous solubility (e.g., > 10 μM) [...] (PZQ), previous and currently used oral anti-schistosomal drugs, possess lower cLogD7.4 values (≤2.5). Furthermore, the lipophilicity associated with PZQ corresponds to a highly permeable and sparingly
Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration (Publications)
challenge in eliminating schistosomiasis. Current approaches to identify hotspots require evaluation 2-5 y after a baseline survey and subsequent mass drug administration. Here, we develop statistical models [...] predicts whether Schistosoma mansoni infection prevalence will exceed the WHO threshold of 10% in year 5 ("prevalence hotspot") with 86% sensitivity, 74% specificity, and 93% negative predictive value (NPV; [...] whether S. mansoni moderate and heavy infection prevalence will exceed a...
Safety and immunogenicity of radiation-attenuated PfSPZ vaccine in equatoguinean infants, children, and adults (Publications)
ed Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment [...] intervals in a randomized, double-blind, placebo-controlled trial stratified by age (6-11 months and 1-5, 6-10, 11-17, 18-35, and 36-61 years). All doses were successfully administered. In all, 192/207 injections [...] occurred in 67/69 vaccinees (97%) and 0/15 controls. Median...
Bisabololoxide derivatives from <em>Artemisia persica</em>, and determination of their absolute configurations by ECD (Publications)
moieties of 1-5 were established on the basis of (3)J(H-H) coupling constants and NOE difference spectra. Stereochemical correlation of the two rings, and assignment of absolute configuration of 1-5 were achieved
Prévalence des diarrhées infantojuvéniles dans deux districts de Nouakchott (Mauritanie) en 2008: analyse de l'influence de l'hygiène du milieu... (Publications)
an average prevalence of 14.8% that varied by age (23.6% in children younger than 5 years and 9.7% among children aged 5 to 14 years) and area (16.8% in Tevragh-Zeina and 28.3% in Sebkha). The univariate
Risk stratification for 1-year mortality in acute heart failure: classification and regression tree analysis (Publications)
patients were categorised to three risk groups: high risk group (BUN > 27.5 mg/dl and age > 86 years), intermediate risk group (BUN > 27.5 mg/dl and age
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5'-monophosphate-mimicking nucleoside sulfamates. The target enzyme catalyzes the formation of an inhibitory [...] inhibitory amino acid-sulfamate conjugate through a reaction-hijacking mechanism. We identified adenosine 5'-sulfamate as a broad-specificity compound that hijacks a range of aaRSs and ML901 as a specific reagent
Inhibitors of PEX14 disrupt protein import into glycosomes and kill <em>Trypanosoma</em> parasites (Publications)
glycosomal/peroxisomal import that depends on the PEX14-PEX5 protein-protein interaction. We developed small molecules that efficiently disrupt the PEX14-PEX5 interaction. This results in mislocalization of glycosomal
Premature atrial contractions in the general population: frequency and risk factors (Publications)
median (interquartile range) number of PACs per hour was 0.8 (0.4-1.8), 1.1 (0.5-2.4), 1.4 (0.7-4.6), 2.3 (0.8-6.9) and 2.6 (1.2-6.5) among participants aged 50-55, 55-60, 60-65, 65-70 and 70+ years, respectively
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
is for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH [...] potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide 2q was identified as