Bisabololoxide derivatives from <em>Artemisia persica</em>, and determination of their absolute configurations by ECD (Publications)
moieties of 1-5 were established on the basis of (3)J(H-H) coupling constants and NOE difference spectra. Stereochemical correlation of the two rings, and assignment of absolute configuration of 1-5 were achieved
Prévalence des diarrhées infantojuvéniles dans deux districts de Nouakchott (Mauritanie) en 2008: analyse de l'influence de l'hygiène du milieu... (Publications)
an average prevalence of 14.8% that varied by age (23.6% in children younger than 5 years and 9.7% among children aged 5 to 14 years) and area (16.8% in Tevragh-Zeina and 28.3% in Sebkha). The univariate
Risk stratification for 1-year mortality in acute heart failure: classification and regression tree analysis (Publications)
patients were categorised to three risk groups: high risk group (BUN > 27.5 mg/dl and age > 86 years), intermediate risk group (BUN > 27.5 mg/dl and age
Premature atrial contractions in the general population: frequency and risk factors (Publications)
median (interquartile range) number of PACs per hour was 0.8 (0.4-1.8), 1.1 (0.5-2.4), 1.4 (0.7-4.6), 2.3 (0.8-6.9) and 2.6 (1.2-6.5) among participants aged 50-55, 55-60, 60-65, 65-70 and 70+ years, respectively
Inhibitors of PEX14 disrupt protein import into glycosomes and kill <em>Trypanosoma</em> parasites (Publications)
glycosomal/peroxisomal import that depends on the PEX14-PEX5 protein-protein interaction. We developed small molecules that efficiently disrupt the PEX14-PEX5 interaction. This results in mislocalization of glycosomal
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
is for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH [...] potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide 2q was identified as
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5'-monophosphate-mimicking nucleoside sulfamates. The target enzyme catalyzes the formation of an inhibitory [...] inhibitory amino acid-sulfamate conjugate through a reaction-hijacking mechanism. We identified adenosine 5'-sulfamate as a broad-specificity compound that hijacks a range of aaRSs and ML901 as a specific reagent
Evaluating putative repellent 'push' and attractive 'pull' components for manipulating the odour orientation of host-seeking malaria vectors in the... (Publications)
was detectable in the air space but with a strong linear reduction in concentrations over 5 m from release. The MB5 constituent chemicals were only irregularly detected, potentially suggesting insufficient [...] positioned in house eave gaps as push components for preventing bites; (ii) understand the efficacy of MB5-baited Suna-traps in attracting vectors in the presence of a human being; (iii) assess 2-butanone as [...] was associated with low nighttime temperatures likely affecting the...
Associations of air pollution and greenness with mortality in Greece: an ecological study (Publications)
studies have documented the adverse effects of long-term exposure to fine particulate matter (PM2.5) on health, while there has been less research on the effects of nitrogen dioxide (NO2), black carbon [...] socioeconomic data were obtained from 1035 municipal units from the 2011 census data. Annual average PM2.5, NO2, BC and O3 concentrations for 2010 were derived from 100 x 100 m surfaces predicted by hybrid LUR [...] and greenness and applied two-exposure models. RESULTS: An interquartile...
Post-exposure lopinavir-ritonavir prophylaxis versus surveillance for individuals exposed to SARS-CoV-2: the COPEP pragmatic open-label, cluster... (Publications)
SARS-CoV-2 PCR positivity, which was 3-fold more frequent in the LPV/r arm (34/209 [16.3%] vs 6/109 [5.5%], respectively). During 21-day follow-up, 48/318 (15.1%) participants developed COVID-19: 35/209 (16 [...] March 2020 to March 2021. Clusters were randomised to receive LPV/r PEP (400/100 mg) twice daily for 5 days or no PEP (surveillance). Exposure to SARS-CoV-2 was defined as a close contact of > 15 minutes [...] 18). Interpretation: The role of LPV/r as PEP for COVID-19 remains...