Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A–D, from a... (Publications)
B4 (4), and four related 5,8′-linked monomeric alkaloids, named ikelacongolines A–D (5a, 5b, 6, and 7). The dimers 3 and 4 are structurally unusual quateraryls comprising two 5,8′-coupled monomers linked [...] were isolated from the here investigated Congolese liana, three of them belonging to the subclass of 5,8′-coupled naphthylisoquinoline alkaloids, whereas two compounds exhibited a less frequently occurring
A 5-year intervention study on elimination of urogenital schistosomiasis in Zanzibar: parasitological results of annual cross-sectional surveys (Publications)
interval (CI): 4.5%-7.6%) to 1.7% (95% CI: 1.2%-2.2%) in 9- to 12-year old students, from 3.9% (95% CI: 2.8%-5.0%) to 1.5% (95% CI: 1.0%-2.0%) in adults, and from 8.8% (95% CI: 6.5%-11.2%) to 2.6% (95% [...] public health problem from Pemba and to interrupt Schistosoma haematobium transmission from Unguja in 5 years. METHODOLOGY: A repeated cross-sectional cluster-randomized trial was implemented from 2011/12 [...] (95% CI: 1.7%-3.5%) in 1st year students from 2011/12 to 2017. In 2017, heavy...
Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from... (Publications)
the Chinese liana Ancistrocladus tectorius (Ancistrocladaceae), two new 5,8'-coupled naphthylisoquinolines, ancistectorine D (5) and its 6-O-demethyl derivative 6, were isolated, along with two new 7,1'-linked [...] (oxidative degradation) and chiroptical (circular dichroism) methods. Chemotaxonomically remarkable, 5,8'-coupled naphthylisoquinolines have as yet been found quite rarely in Asian Ancistrocladus species [...] coupling type represent the by far the largest group of constituents in...
Low sensitivity of the MPT64 identification test to detect lineage 5 of the <em>Mycobacterium tuberculosis</em> complex (Publications)
the rapid MPT64 antigen identification test for the detection of Mycobacterium africanum lineage 5 (MAF L5). METHODOLOGY: Smear-positive tuberculosis patients' sputa were included prospectively. Culture [...] MTBc isolates (93.2 %, 300/322), but it failed to detect 24 % of the L5 isolates (18/75) versus 2 % (4/202) of the L4 ones [OR=15.6 (5.3-45.8), P
Bayesian geostatistical modelling of PM10 and PM2.5 surface level concentrations in Europe using high-resolution satellite-derived products (Publications)
pollutants and remotely sensed predictors were developed to estimate yearly averages of both, fine (PM2.5) and coarse (PM10) surface PM concentrations, at 1km(2) spatial resolution over 46 European countries [...] predictive ability of the frequently employed land-use regression. The resulting estimates of PM10 and PM2.5, which represent the main air quality indicators for the urban Sustainable Development Goal, indicate
Land use regression modelling of outdoor NO2 and PM2.5 concentrations in three low income areas in the Western Cape Province, South Africa (Publications)
NO(2) and PM2.5 were 22.1 μg/m(3) and 10.2 μg/m(3), respectively. The NO(2) models for the warm season, cold season, and overall year explained 62%, 77%, and 76% of the variance (R(2)). The PM2.5 annual models [...] Explanatory power for PM2.5 models is lower due to lower spatial variability and the possible impact of local transient sources. The study was able to provide NO(2) and PM2.5 seasonal exposure estimates [...] can help to inform communities, industries, and policy makers. Weekly...
Acute-phase proteins and mortality in status epilepticus: a 5-year observational cohort study (Publications)
OBJECTIVE: Acute-phase proteins, such as C-reactive protein and albumin, may be related with course and outcome in status epilepticus, as changes of cytokine levels and blood-brain barrier breakdown d
Re-estimated equations for 5th percentiles of lung function variables (Letter to editors) (Publications)
applied extrapolations of the 5th percentile curves to men aged between 60 and 70 years2 and have found that for some of the lung function parameters---for example, FEV1---the 5th percentiles appeared to get [...] In 1996 we published reference equations for the 5th percentiles of lung function parameters (FVC, FEV1, PEF, FEF25, FEF50, FEF75, FEF25-75, FEV1/FVC) as a function of age and height.1 These reference