Patient-reported barriers to adherence to antiretroviral therapy: a systematic review and meta-analysis (Publications)
CI 20.1%-38.4%), being away from home (adults 30.4%, 95% CI 25.5%-35.2%; adolescents 40.7%, 95% CI 25.7%-55.6%; children/caregivers 18.5%, 95% CI 10.3%-26.8%), and a change to daily routine (adults 28 [...] reported as a barrier to adherence by more than 15% of patients across all age categories (adults 15.5%, 95% CI 12.8%-18.3%; adolescents 25.7%, 95% CI 17.7%-33.6%; children 15.1%, 95% CI 3.9%-26.3%), while [...] children across all regions (adults 13.6%, 95% CI 11.9%-15.3%;...
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and... (Publications)
falciparum (IC(50) 1.5 and 1.7muM) with good selectivity (SI approximately 80). The 4-tert-butyl aniba-dimer A analogue 33 also exhibited activity towards L. donovani (IC(50) 4.5muM), suggesting further [...] analogues were typically less active or lacked selectivity. Head-to-head and head-to-tail photodimers 5 and 34 exhibited moderate IC(50)s of 2.3 to 17muM towards several of the parasitic organisms, while
High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities (Publications)
above a threshold, respiratory admissions increased by +4.5% (95% confidence interval, 1.9-7.3) and +3.1% (95% confidence interval, 0.8-5.5) in the 75+ age group in Mediterranean and North-Continental
Short-term effects of air pollution on total and cardiovascular mortality: the confounding effect of influenza epidemics (Publications)
associated with particulates (PM10). We used 10 methods to control for epidemics (5 derived from influenza data and 5 from respiratory mortality series) and compared those results with analyses that did [...] cases (% change in the pooled regression coefficient: -1.9 to 38.9 for total mortality and 1.3 to 25.5 for cardiovascular mortality). A 10-microg/m increase in PM10 concentrations (lag 0-1) was associated
Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease (Publications)
in 1 hour mean outdoor PM2.5 before the HRV measurement and a change in HF-HRV power in individuals with CVD (3% increase in median HF-HRV (95% CI -19 to 32)) or without CVD (5% decrease in median HF-HRV [...] (95% CI -34 to 36)). Similarly, no association was evident using 4 hour and 24 hour mean outdoor PM2.5 exposures before the HRV measurement. CONCLUSION: No association was found between increased residence
Spatial variability of nitrogen dioxide and formaldehydeand residential exposure of children in the industrial area of Viadana, Northern Italy (Publications)
with hot-spots in proximity to theindustry. PM10and PM2.5exposures were higher for children at < 1 km compared to the children living at > 3.5 km to theindustry, whereas NO2exposure was higher at 1–1 [...] as well as other available countrywide/continental models basedon routine data on NO2, PM10, andPM2.5. The correlation between NO2concentrations from continuous and passive samplingwas high (Pearson’sr=
Population pharmacokinetics of antimalarial naphthoquine in combination with artemisinin in Tanzanian children and adults: dose optimization (Publications)
adults and children over 5 years of age (6 to 10, 11 to 17, and > /=18 years of age) with uncomplicated malaria in Tanzania. The median weights for the three age groups were 20, 37.5, and 55 kg, respectively [...] weight and 44.3-kg fat-free mass) were estimated as 66.7 L/h (95% confidence interval [CI], 57.3 to 78.5 L/h) for artemisinin and 44.2 L/h (95% CI, 37.9 to 50.6 L/h) for naphthoquine. Nevertheless, we show
The combination of HIV and alcohol use internalized stigmas are associated with greater symptoms of depression in a South African sample living with... (Publications)
04), greater rumination (B = 5.72, p = .02), and greater work/school impairment (B = 3.94, p = .01). High internalized alcohol (B = -5.97, p = .009) or HIV stigma (B = -5.25, p = .02) alone was significantly
Associations of preconception exposure to air pollution and greenness with offspring asthma and hay fever (Publications)
Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µg/m3) and greenness (normalized [...] stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32–3 [...] medium O3 exposure (OR 4.15, 95%CI 1.28–13.50) and mothers with high...
Long-term exposure to traffic-related air pollution and stroke: a systematic review and meta-analysis (Publications)
μg/m3 PM10, 1.08 (0.89–1.32) per 5 μg/m3 PM2.5, 0.98 (0.92; 1.05) per 10 μg/m3 NO2 and 0.99 (0.94; 1.04) per 20 μg/m3 NOx with little to moderate heterogeneity based on 6, 5, 4, 7 and 8 studies, respectively
