Alternative complement pathway inhibition does not abrogate meningococcal killing by serum of vaccinated individuals (Publications)
and D, C3, C5 and MASP-2 inhibitors. B meningococci were not included in this study since the immune response against protein-based vaccines is more complex. Unsurprisingly, inhibition of C5 abrogated killing [...] conditions can be treated with monoclonal antibodies (mAbs) that bind to the complement component C5 and prevent formation of the membrane attack complex (MAC). While MAC is involved in uncontrolled lysis
Recovery of left ventricular systolic function in peripartum cardiomyopathy: an observational study from rural Tanzania (Publications)
function (left ventricular ejection fraction > 50%). RESULTS: Median age of the 110 participants was 28.5 years (range 17-45). At enrolment, 49 (45%) participants were already on cardiac medication, 50 (45%) [...] left ventricular ejection fraction was 30% (range 15-46). After a median follow-up of 8.98 months (IQR 5.72-29.37), 61 (55%) participants were still on cardiac medication. Full recovery of the left ventricular [...] higher left ventricular ejection fraction at baseline was positively...
Large gains in schooling and income are possible from minimizing adverse birth outcomes in 121 low- and middle-income countries: a modelling study (Publications)
9.8 million school years (95% CI: 1.5,18.4) and US$ 41.9 billion (95% CI: 6.1,80.9) in lifetime income. The potential gains from small-for-gestational age were 39.5 million (95% CI: 19.1,60.3) school years [...] years and US$113.6 billion (95% CI: 55.5,174.2) in lifetime income gained. In summary, reducing the excess prevalence of low birthweight, preterm birth or small-for-gestational age births in low- and
Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later (Publications)
to 7.8) and the regression estimates (95%CI) for FEV1% predicted varied from 0.6 (-3.5 to 4.6) to -9.9 (-14.2 to -5.5) between clusters. Change of FEV1 over time did not differ significantly across clusters
Pharmacokinetics of albendazole, albendazole sulfoxide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of... (Publications)
pamoate. Similar half-life (t1/2 approximately 1.5 h), time to reach the maximum concentration (tmax approximately 2 h) and maximum concentration (Cmax = 12.5-26.5 ng/mL) of albendazole were observed in the
<em>Ent</em>-pimarane and <em>ent</em>-kaurane diterpenes from <em>Aldama discolor</em> (Asteraceae) and their antiprotozoal activity (Publications)
ent-kaurane 1 showed significant in vitro activity against both P. falciparum (IC 50 = 3.5 mu M) and L. donovani (IC 50 = 2.5 mu M) and ent-pimarane 2 against P. falciparum (IC 50 = 3.8 mu M). Both compounds [...] candidates for in vivo tests. In addition to the diterpenes, the sesquiterpene lactone budlein A (5), which has been reported to possess a strong anti-T. b. rhodesiense activity, was identified as major
Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts (Publications)
PMcoarse OR 1.31 (1.05 to 1.64) per 5 microg/m3 increase and PM10 with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs (black carbon) exposures. [...] Cohorts for Air Pollution Effects (ESCAPE) project. METHODS: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE
The genomes of three stocks comprising the most widely utilized live sporozoite <em>Theileria parva</em> vaccine exhibit very different degrees and... (Publications)
families. The Kiambu5 isolate is considerably more divergent, with close to 40,000 SNPs relative to Muguga, including > 8,500 non-synonymous mutations distributed among > 1,700 (42.5 %) of the predicted [...] the three component T. parva stocks within this vaccine, the Muguga Cocktail, namely Muguga, Kiambu5 and Serengeti-transformed, aiming to identify genomic features that contribute to vaccine efficacy.
Efficacy and safety of ivermectin against <em>Trichuris trichiura </em>in preschool- and school-aged children: a randomized controlled dose-finding... (Publications)
cure rates (20.9% [95% CI 11.9-52.8%] vs. 19.5% [95% CI 10.4-49.9%]) and geometric mean egg-reduction rates (78.6% [95% CI 60.1-89.5%] vs. 68.2% [95% CI 40.5 to 84.8%]). In school-aged children even a dose
Antiprotozoal diterpenes from <em>Perovskia abrotanoides</em> (Publications)
IC50 of 2.9 microM (SI 19.2) against P. falciparum, and miltiodiol (10: ) with an IC50 of 0.5 microM (SI 10.5) against T. b. rhodesiense. None of the compounds exhibited selective toxicity against T. cruzi [...] -17: ), including 14 abietane-, two icetexane-, and one isopimarane-type derivatives. Among these, (5R,10S)-11-hydroxy-12-methoxy-20-norabieta-8,11,13-triene (2: ), 12-hydroxy-norabieta-1(10),8,11,13-tetraene-1
