Antimalarial dibenzannulated medium-ring keto lactams (Publications)
keto lactams (11,12-dihydro-5H-dibenzo[b,g]azonine-6,13-diones) as a new antimalarial chemotype. Most of these had chromatographic LogD(7.4) values ranging from 100 μg/mL at pH 6.5). The more polar compounds
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
dose, 5% (7/136) and 28% (35/123) of infants in OD and MD arms respectively had plasma gentamicin concentrations or =2 microg/ml (a surrogate of potential treatment toxicity) were found in 6% (5/89) and
Health-related quality of life, psychosocial work conditions, and absenteeism in an industrial sample of blue- and white-collar employees: a... (Publications)
manufacturing plant in Germany. Frequency indices were the number of sick-leave spells of 1, 2-3, 4-5, and > 5 days within 1 year. RESULTS/CONCLUSION: Effort-reward imbalance, lack of support by supervisors
Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities (Publications)
MEASURES: Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. RESULTS: On average, a 10 mug/m(3) increase in NO2 concentration
Incidence of human granulocytic anaplasmosis in returning travelers with fever (Publications)
person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA. CONCLUSIONS: Diagnosis of HGA and empirical treatment
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
dose, 5% (7/136) and 28% (35/123) of infants in OD and MD arms respectively had plasma gentamicin concentrations or =2 microg/ml (a surrogate of potential treatment toxicity) were found in 6% (5/89) and
Health-related quality of life, psychosocial work conditions, and absenteeism in an industrial sample of blue- and white-collar employees: a... (Publications)
manufacturing plant in Germany. Frequency indices were the number of sick-leave spells of 1, 2-3, 4-5, and > 5 days within 1 year. RESULTS/CONCLUSION: Effort-reward imbalance, lack of support by supervisors
Long-term outcome after SARS-CoV-2 infection in healthcare workers: a single centre cohort study (Publications)
infected with SARS-CoV-2. RESULTS: Persistent symptoms at 3 and 12 months were reported by 26.5% and 13.5% of participants, respectively. Most commonly reported symptoms were fatigue, impaired sense of
Synthesis and in vitro and in vivo evaluation of antimalarial polyamines (Publications)
2-Hydroxy and 2,5-dimethoxy analogues were typically found to exhibit the most potent activity towards the dual drug resistant strain K1 of P. falciparum with IC50's in the range of 1.3-9.5 nM, and selectivity
Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives (Publications)
azone derivatives, designed through molecular hybridization between the (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)prop-2-en-1-one and (E)-3-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)-7-m [...] and bloodstream forms of Trypamosoma brucei rhodesiense. The derivative (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-phenylmethylene]acrylohydrazi de showed moderate antileishmanial activity (IC50