Detection of pathogens of acute febrile illness using polymerase chain reaction from dried blood spots (Publications)
viruses. Plasmodium spp. was consistently detected from DBS but yielded a mean cycle threshold (Ct) 5.7 +/- 1.6 higher than that from whole blood samples. A DBS qPCR Ct cutoff of 27 yielded 94.1% sensitivity [...] for malaria diagnosis. For other pathogens investigated, DBS testing yielded a sensitivity of only 8.5% but a specificity of 98.6% compared with whole blood qPCR. In sum, direct PCR of DBS had reasonable
Detection of mostly viral pathogens and high proportion of antibiotic treatment initiation in hospitalised children with community-acquired pneumonia... (Publications)
Fever (obligatory for enrolment) had been present for median 5 days before admission. Most common symptoms were reduced activity (129, 93.5%) and reduced oral intake (108, 78.3%). Oxygen saturation
Economic burden of underweight and overweight among adults in the Asia-Pacific region: a systematic review (Publications)
and estimate that it accounts for 1.5% to 9.9% of a country's total health care expenditure. Four articles on the economic burden of underweight estimate it at 2.5% to 3.8% of the country's total GDP.
HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis (Publications)
to occur in sympatric compared to allopatric host-pathogen combinations (adjusted odds ratio [OR] 7.5, 95% confidence interval [95% CI] 1.21-infinity, p = 0.03). HIV infection was significantly associated [...] with TB caused by an allopatric (as opposed to sympatric) M. tuberculosis lineage (OR 7.0, 95% CI 2.5-19.1, p
Outcome of delivery and cause-specific mortality and severe morbidity in early infancy: a Kenyan District Hospital birth cohort (Publications)
were delivered. Of these, 136 (6%) were stillborn and 77 (3.5%) subsequently died. Prematurity (34%), birth asphyxia (27%), and infection (18.5%) were the predominant causes of death in the first 98 days
beta-Branched acyclic nucleoside analogues as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
beta-branched acyclic tritylated deoxyuridine analogues as inhibitors of Plasmodium falciparum deoxyuridine-5'-triphosphate nucleotidohydrolase (PfdUTPase), an enzyme involved in nucleotide metabolism that acts [...] potency and selectivity compared with previously reported analogues. The best inhibitor gave a K(i) of 0.5muM against PfdUTPase with selectivity greater than 200-fold compared to the corresponding human enzyme
The Basel early-detection-of-psychosis (FEPSY)-study--design and preliminary results (Publications)
examined extensively and followed-up for at least 5 years to detect actual transition to psychosis. RESULTS: Of 50 subjects who have been followed up for 1-5 years by now, 16 have progressed to frank psychosis
Independent contribution of parental migrant status and educational level to adiposity and eating habits in preschool children (Publications)
independent contribution in preschoolers. SUBJECTS/METHODS: Of 655 randomly selected preschoolers, 542 (5.1+/-0.6 years; 71% of parental MS and 37% of low parental EL) were analysed. Body composition was measured [...] fruit and vegetables', (3) 'Decreasing breakfast skipping', (4) 'Reducing fatty and sweet foods' and (5) 'Reducing the intake of meals and snacks in front of television'. RESULTS: Children of migrant and
Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African... (Publications)
biological evaluation of three series of 6-phosphogluconate (6PG) analogues is described. (2R)-2-Methyl-4,5-dideoxy, (2R)-2-methyl-4-deoxy and 2,4-dideoxy analogues of 6PG were tested as inhibitors of 6-phos [...] inhibitors belong to the (2R)-2-methyl-4-deoxy series (6, 8, 10, 12, 21, 24) and one is a (2R)-2-methyl-4,5-dideoxy analogue (29b). The 2,4-dideoxy analogues of 6PG did not inhibit both enzymes. The trypanocidal
Detection of mostly viral pathogens and high proportion of antibiotic treatment initiation in hospitalised children with community-acquired pneumonia... (Publications)
Fever (obligatory for enrolment) had been present for median 5 days before admission. Most common symptoms were reduced activity (129, 93.5%) and reduced oral intake (108, 78.3%). Oxygen saturation
