Recherche de 5.

1. Development of PM2.5 and NO2 models in a LUR framework incorporating satellite remote sensing and air quality model data in Pearl River Delta region,... (Publications)

   Development of PM2.5 and NO2 models in a LUR framework incorporating satellite remote sensing and air quality model data in Pearl River Delta region, China

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2. Elemental composition and oxidative properties of PM2.5 in Estonia in relation to origin of air masses - results from the ECRHS II in Tartu (Publications)

   Elemental composition and oxidative properties of PM2.5 in Estonia in relation to origin of air masses - results from the ECRHS II in Tartu

   Pertinence:

   Fine particulate matter (PM(2.5)) was sampled at an urban background site in Tartu, Estonia over one-year period during the ECRHS II study. The elemental composition of 71PM(2.5) samples was analyzed for different [...] oxidative properties were correlated to the origin of air masses. The OH values were approximately 1.5 times higher when air masses originated from the direction of "Eastern Europe" or "Russia." The origin [...] measured particles was evaluated using principal component factor...

3. Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds (Publications)

   Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

   Pertinence:

   A small series of 5-nitro-2-aminothiazole-based amides containing arylpiperazine-, biphenyl- or aryloxyphenyl groups in their core were synthesized and evaluated as antitrypanosomatid agents. All tested

4. Immunologic-based diagnosis of latent tuberculosis among children less than 5 years of age exposed and unexposed to tuberculosis in Tanzania:... (Publications)

   Immunologic-based diagnosis of latent tuberculosis among children less than 5 years of age exposed and unexposed to tuberculosis in Tanzania: implications for tuberculosis infection screening

   Pertinence:

   those with and without exposure: 20% (38/186) vs. 20% (23/115) QFT-positive, and 2% (4/186) vs. 4% (5/115) indeterminate QFT. QFT conversion rate was 7% (22 children) and reversion 8% (25 children). Of

5. Spatial PM2.5, NO2, O3 and BC models for Western Europe - evaluation of spatiotemporal stability (Publications)

   Spatial PM2.5, NO2, O3 and BC models for Western Europe - evaluation of spatiotemporal stability

   Pertinence:

   health relevant air pollutants (PM2.5, NO2, BC, O3) across Europe. METHODS: We developed West-European land use regression models (LUR) for 2010 estimating annual mean PM2.5, NO2, BC and O3 concentrations [...] time, separate models were developed for different years (NO2 and O3: 2000 and 2005; PM2.5: 2013). RESULTS: The PM2.5, BC, NO2, O3 annual, O3 warm season and O3 cold season models explained respectively 72% [...] and 16% of the R(2) in the PM2.5, O3 warm and O3 cold models. Explained...

6. Comparative genomics of <em>Mycobacterium africanum</em> lineage 5 and lineage 6 from Ghana suggests distinct ecological niches (Publications)

   Comparative genomics of <em>Mycobacterium africanum</em> lineage 5 and lineage 6 from Ghana suggests distinct ecological niches

   Pertinence:

   Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve neutrally in L5 but under [...] epitopes overall compared to L5. Of the 10% human T cell epitopes that were variable, most carried mutations that were lineage-specific. Our findings indicate that Maf L5 and L6 differ in some of their

7. 5. Jahresbericht des Schweizerischen Tropeninstituts in Basel 1948 (Publications)

   5. Jahresbericht des Schweizerischen Tropeninstituts in Basel 1948

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8. Long-lasting insecticidal nets retain bio-efficacy after 5 years of storage: implications for malaria control programmes (Publications)

   Long-lasting insecticidal nets retain bio-efficacy after 5 years of storage: implications for malaria control programmes

   Pertinence:

   effective LLINs in endemic areas are required. This study evaluated whether LLINs that had been stored for 5 years under manufacturer's recommended conditions may be optimally effective against Anopheles mosquitoes [...] y and wash resistance of Olyset((R)) and DawaPlus((R)) 2.0 (rebranded Tsara((R)) Soft) LLINs after 5 years of storage at 25 degrees C to 33.4 degrees C and 40% to 100% relative humidity. In addition, a [...] s.) (Ifakara strain) and pyrethroid resistant Anopheles arabiensis...

9. Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among... (Publications)

   Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries

   Pertinence:

   Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income). [...] Cost-Effectiveness poLicy (MCMARCEL) was developed to follow RSV-related events monthly from birth until 5 years of age. MCMARCEL was parameterised using country- and age-specific demographic, epidemiological

10. Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity (Publications)

    Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity

    Pertinence:

    existing therapies are partially ineffective and cause serious adverse effects. Formation of the PEX14-PEX5 complex is essential for protein import into the parasites' glycosomes. This transport is critical for [...] on of glycosomal enzymes, with fatal consequences for the parasite. Hence, inhibiting the PEX14-PEX5 protein-protein interaction (PPI) is an attractive way to affect multiple metabolic pathways. Herein [...] computational screening and optimization to develop the first line of...