Long-term outcomes of ivermectin-albendazole <em>versus </em>albendazole alone against soil-transmitted helminths: results from randomized controlled... (Publications)
95% CI 42.6-61.0; ERRs: 99.6 vs 91.3, difference 8.3; 95% CI 5.7-10.8) and Pemba Island (CR, 19.5 vs 3.4%, difference; 16.1; 95% CI 10.7-21.5; ERRs: 92.9 vs 53.6, difference 39.3; 95% CI 31.2-47.4) respectively [...] considerably higher on Pemba Island (100.0%, 95% CI, 29.2-100.0) than in Lao PDR (10.0%, 95% CI, 0.2-44.5) at 12 months post-treatment for participants treated with albendazole alone. CONCLUSIONS/SIGNIFICANCE:
Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants (Publications)
17 showed good antiplasmodial activity (IC50 0.04-5.0 microg/ml), 7 exhibited moderate anti-trypanosomal activity (IC50 2.3-2.8 microg/ml), while 5 displayed mild anti-leishmanial activity (IC50 8.8-9
National intestinal helminth survey among schoolchildren in Tajikistan: prevalences, risk factors and perceptions (Publications)
the country, prevalences of E. vermicularis, A. lumbricoides, H. nana and T. trichiura were 26.5%, 16.9%, 15.5% and 2.7% respectively. The prevalence of common soil-transmitted helminth (A. lumbricoides and
Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from <em>Salvia miltiorrhiza</em> (Publications)
tanshinone II a ( 2), 1,2 dihydrotanshinquinone ( 3), methylenetanshinquinone ( 4), 1-oxomiltirone ( 5), 11-hydroxymiltiodiol ( 6), tanshinone I ( 7), methyltanshinonate ( 8), and cryptotanshinone ( 9). [...] selectivity indices (SI) from 0.3 to 1.9. IC (50)s against T. BRUCEI RHODESIENSE STIB 900 were from 0.5 microM ( 1, 4) to over 30 microM, and 4 showed the greatest selective activity with an SI of 24
Epidemiology of schistosomiasis in two high-risk communities of south Côte d'Ivoire with particular emphasis on pre-school-aged children (Publications)
in school-aged children (58.7-68.4%) and adolescents/adults (59.5-61.7%). The prevalence of S. haematobium in the three age groups was 5.9-17.3%, 10.9-18.4%, and 3.8-21.3%, respectively. Most participants
Rapid re-infection with soil-transmitted helminths after triple-dose albendazole treatment of school-aged children in Yunnan, People's Republic of... (Publications)
were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half harboring triple-species infections. For the intervention group (N = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and
Unusual derivatives from <em>Hypericum scabrum</em> (Publications)
an unexpected cycloheptane ring decorated with prenyl substituents, and compound 3 has an unusual 5,5-spiroketal lactone core. Their structures were determined by extensive spectroscopic and spectrometric
Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens... (Publications)
specific to whole asexual parasites and to recombinant MSP-1(19), AMA-1, and EBA-175 were measured at ages 5, 9, 12, and 24 months for 302 children by immunofluorescence antibody tests and by enzyme-linked im [...] MSP-1(19), which were significantly higher in the SP-treated group than in the placebo group at ages 5, 9, and/or 24 months. IPTi with SP given through the EPI reduces the frequency of malarial illness while
Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation (Publications)
prevalence of Chagas disease was 2.3% among migrants (15.5% in the community testing) and 0% among travellers. The prevalence was 18.0%, 0.8%, 0.5% and 0% among Bolivians, Ecuadorians, Brazilians and other
Prevalence and outcomes of hepatitis B coinfection and associated liver disease among antiretroviral therapy-naive individuals in a rural Tanzanian... (Publications)
associated with significant liver fibrosis (aspartate aminotransferase-to-platelet ratio index [APRI] > 1.5) and cirrhosis (APRI > 2.0) were identified using logistic regression. Results. Of 3097 individuals [...] antigen (HBsAg) positive. Before ART initiation, 9.1% individuals had significant liver fibrosis and 5.3% had cirrhosis. Human immunodeficiency virus/HBV-coinfected individuals were more likely to have an