Sustaining the control of <em>Schistosoma mansoni</em> in western Côte d'Ivoire: baseline findings before the implementation of a randomized... (Publications)
Overall, 4,953 first graders (aged 5-8 years) and 7,011 schoolchildren (aged 9-12 years) had complete parasitologic data. The overall prevalence of S. mansoni was 5.4% among first graders and 22.1% in
Associations between air pollution and socioeconomic characteristics, ethnicity and age profile of neighbourhoods in England and the Netherlands (Publications)
and elderly). We saw higher concentrations in the most deprived 20% of neighbourhoods in England (1.5 µg/m(3) higher PM10 and 4.4 µg/m(3) NO2). Concentrations in both countries were higher in neighbourhoods [...] (England: 3.0 µg/m(3) higher PM10 and 10.1 µg/m(3) NO2; the Netherlands: 1.1 µg/m(3) higher PM10 and 4.5 µg/m(3) NO2) after adjustment for urbanisation and other variables. Associations for some areas differed
Multiple loci associated with indices of renal function and chronic kidney disease (Publications)
CKD cases). We identified significant SNP associations (P < 5 x 10(-8)) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1. UMOD encodes the most
<em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study (Publications)
promising antiparasitic activity against Trypanosoma brucei rhodesiense with IC50 values between 2.5 and 10.0microM and selectivity index (SI) ranged from 0.8 to 13.2. Eight compounds exhibited activity [...] against Plasmodium falciparum K1 strain with IC50 ranging 1.7-6.4microM, and SI values between 2.8 and 10.5 against L6 rat myoblast cell lines. Molecular docking was carried out on trypanothione reductase (TbTR
Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana <em>Ancistrocladus ealaensis</em> (Publications)
ally unsymmetric dimers are the first stereochemically fully assigned cross-coupling products of a 5,8'- and a 7,8'-coupled naphthylisoquinoline linked via C-6' in both naphthalene portions. So far, only [...] dimers with a central 6,6''-axis, yet, in contrast to the ealapasamines, usually consisting of two 5,8'-coupled monomers, like e.g., in michellamine B. The new dimers 1-3 contain six elements of chirality
Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study (Publications)
of IFN-gamma, TNF-alpha, IL-5, IL-10, and IL-12. RESULTS: Significantly higher levels of IFN-gamma and TNF-alpha in farm compared with nonfarm children were found, whereas IL-5, IL-10, and IL-12 levels did
Prophylactic effect of artemether on human <em>Schistosomiasis mansoni</em> among Egyptian children: a randomized controlled trial (Publications)
PZQ twice four weeks apart, after which one group received 6mg/kg body weight of ART every 3 weeks in 5 cycles during the transmission season and the other group received ART-placebo. At the end of the study [...] o group, i.e. 6.7% versus 11.6%, and incidence of new infections for the PZQ/ART was 2.7% versus 6.5% for the PZQ/ART-placebo. In conclusion, PZQ/ART combined therapy might be considered as an adjunct
Phytochemical study of <em>Salvia leriifolia</em> roots: rearranged abietane diterpenoids with antiprotozoal activity (Publications)
performed via extensive NMR and HRESIMS data, and the absolute configurations of compounds 1 and 3-5 were established by evaluation of experimental and calculated ECD spectra. The antiplasmodial activity [...] proposed. Leriifoliol (1) is the first 20- nor-9,10- seco-abietane, while 2 exhibits an uncommon 6-6-5 fused-ring system.
An observational study of material durability of three World Health Organization-recommended long-lasting insecticidal nets in eastern Chad (Publications)
were recorded by using three hole categories (average diameter = 2, 3.5, and 15 cm) and a Proportionate Hole Index (pHI). A total of 69.5% were in poor or very poor condition. There was no significant difference
Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes (Publications)
patients selected randomly from 4221 registered patients were analyzed. The registry sample included 10 (3.5%) coinfected patients not enrolled in the SHCS: the estimated number of HIV-infected patients not enrolled [...] 2000-2008 was 146 (95% CI 122-173). Coinfected patients were more likely to be from sub-Saharan Africa (51.5% versus 15.8%, P