Sustaining the control of <em>Schistosoma mansoni</em> in western Côte d'Ivoire: baseline findings before the implementation of a randomized... (Publications)
Overall, 4,953 first graders (aged 5-8 years) and 7,011 schoolchildren (aged 9-12 years) had complete parasitologic data. The overall prevalence of S. mansoni was 5.4% among first graders and 22.1% in
Prevalence and outcomes of hepatitis B coinfection and associated liver disease among antiretroviral therapy-naive individuals in a rural Tanzanian... (Publications)
associated with significant liver fibrosis (aspartate aminotransferase-to-platelet ratio index [APRI] > 1.5) and cirrhosis (APRI > 2.0) were identified using logistic regression. Results. Of 3097 individuals [...] antigen (HBsAg) positive. Before ART initiation, 9.1% individuals had significant liver fibrosis and 5.3% had cirrhosis. Human immunodeficiency virus/HBV-coinfected individuals were more likely to have an
Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation (Publications)
prevalence of Chagas disease was 2.3% among migrants (15.5% in the community testing) and 0% among travellers. The prevalence was 18.0%, 0.8%, 0.5% and 0% among Bolivians, Ecuadorians, Brazilians and other
<em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study (Publications)
promising antiparasitic activity against Trypanosoma brucei rhodesiense with IC50 values between 2.5 and 10.0microM and selectivity index (SI) ranged from 0.8 to 13.2. Eight compounds exhibited activity [...] against Plasmodium falciparum K1 strain with IC50 ranging 1.7-6.4microM, and SI values between 2.8 and 10.5 against L6 rat myoblast cell lines. Molecular docking was carried out on trypanothione reductase (TbTR
Modeling the persistence of 4CMenB vaccine protection against real world meningococcal B disease in adolescents (Publications)
long-lived plasma cells. 4CMenB protection from real-world MenB disease persisted at 61.5% four years post-priming and 70.5% four years post-booster. This evidence could support decision-making on adolescent
Anonymous HIV surveillance with risk-factor elicitation: at Perth (for men) and Cornton Vale (for women) prisons in Scotland (Publications)
prevalence of 1.4% (6/434), giving a 1.5 ratio of overall: disclosed HIV prevalence at HMP Perth. HIV prevalence was estimated at 7% (6/82) for injector-participants and 14% (5/35) for local injector participants [...] (64%: 38/60) were injectors than of women prisoners from the Edinburgh, Dundee and Fife area (21%: 5/26) or from elsewhere (34%: 15/45). Rape was reported by 23% of women (30/130). Women who had been raped [...] in by 19% of female injector-inmates (11/57) and was acknowledged by...
11C-choline PET/CT predicts prostate cancer-specific survival in patients with biochemical failure during androgen-deprivation therapy (Publications)
confidence interval [CI], 1.7-18.9 y). The median follow-up after 11C-choline PET/CT was 4.5 y (95% CI, 0.4-8.5 y). 11C-choline PET/CT results were positive in 57% of patients. The median PCa-specific survival [...] survival (median, 12.1 y; 95% CI, 10.5-13.7 y) in comparison to patients with pathologic tracer uptake in the skeleton (median, 9.9 y; 95% CI, 6.8-13.1 y) (log-rank: chi2 = 6.5, P = 0.010). Two internally validated
Low prevalence of <em>Plasmodium</em> and absence of malaria transmission in Conakry, Guinea: prospects for elimination (Publications)
Health statistical yearbooks was performed to determine malaria prevalence in children below the age of 5 years. RESULTS: Culex larval breeding sites were observed in large numbers throughout Conakry in both [...] remaining 10 (8.9 %) were An. melas. The molecular M form of An. gambiae s.s. was predominant (n = 89; 79.5 %). The proportions of kdr genotype in the An. gambiae s.s. M and S form were 65.2 and 81.8 % (n = 9) [...] detected in any of the mosquitoes tested. The prevalence of Plasmodium...
Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models (Publications)
children. A positive impact is also predicted at a PfPR2-10 of 5-10%, but there is little impact at a prevalence of lower than 3%. At $5 per dose and a PfPR2-10 of 10-65%, we estimated a median incremental [...] trial data for follow-up of 32 months or longer to parameterise vaccine protection in the group aged 5-17 months. Estimates of cases, deaths, and disability-adjusted life-years (DALYs) averted were calculated [...] 2-10 year olds (PfPR2-10; range 3-65%). We considered two vaccine...
Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a... (Publications)
reported in 57/170 infants who received RTS,S/AS02D (33.5%; 95% confidence interval [CI]: 26.5, 41.2) and 62/170 infants who received hepatitis B vaccine (36.5%; 95% CI: 29.2, 44.2). The SAE profile was similar [...] protocol population, vaccine efficacy against multiple episodes of malaria disease was 50.7% (95% CI: -6.5 to 77.1, p = 0.072) and 26.7% (95% CI: -33.1 to 59.6, p = 0.307) over 12 and 18 months post vaccination