Germline Elongator mutations in Sonic Hedgehog medulloblastoma (Publications)
genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children(1,2), and genetic events that cooperate with known somatic driver [...] Pathogenic germline variants in established cancer predisposition genes have been recently identified in 5% of patients with the malignant brain tumour medulloblastoma(3). Here, by analysing all protein-coding [...] which catalyses translational elongation through tRNA modifications...
Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts (Publications)
Respiratory Health Survey) were included. Annual exposure to NO2, PM10, PM2.5, and PMcoarse (calculated by subtracting PM2.5 from PM10) was estimated using land-use regression models derived from the European [...] moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM2.5. Higher exposure to NO2 was associated with an increased severity of rhinitis, with similar adjusted
Investigation of antiplasmodial effects of terpenoid compounds isolated from myrrh (Publications)
lide (4: ), 2-methoxyisogermafurenolide (5: ), 8-epi-2-methoxyisogermafurenolide (6: ), furanodienone (7: ), 1(10)Z,4Z-furanodien-6-one (8: ), rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one [...] compounds were identified by MS and NMR spectroscopic analyses. To the best of our knowledge, compounds 5, 6, 12, 13, 16, 18: , and 20: are reported for the first time. All isolated compounds were tested in
Limited sampling models to predict the pharmacokinetics of nevirapine, stavudine, and lamivudine in HIV-infected children treated with pediatric... (Publications)
-0.6%, 95% confidence interval: -2.2 to +1.0; rmse%: 6.5%; r: 0.98) and lamivudine AUC (mpe%: -0.3%, 95% confidence interval: -1.7 to +1.1; rmse%: 5.6%; r: 0.99) was found; this model was also highly accurate [...] 6-hour sample was acceptable for nevirapine (mpe%: -0.8%, 95% confidence interval: -2.2 to +0.6); rmse%: 5.8%; r: 0.98). Using two samples, AUC predictions for stavudine and lamivudine improved considerably
Weight status and gender-related differences in motor skills and in child care-based physical activity in young children (Publications)
randomly selected for the Youp'la bouge study. Motor skills were assessed by an obstacle course including 5 motor skills, derived from the Zurich Neuromotor Assessment test. Physical activity was measured with [...] differences were found in the overall motor skills score, but boys performed better than girls in 2 of the 5 motor skills (p [less than or equal to] 0.04). Total physical activity as well as time spent in mod [...] moderate-vigorous and in vigorous activity during child care...
Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study (Publications)
We found that increasing maternal age was associated with incidence of ALL in the offspring (OR per 5-year increase in maternal age 1.18, 95% CI 1.05-1.31; p = 0.004), remaining stable (trend OR 1.14, 95% [...] 060) after adjustment for other risk factors. The association with paternal age was weaker (OR per 5-year increase 1.14, 95% CI 1.01-1.28, p = 0.032) and disappeared after adjustments. Number of older [...] years (OR per sibling 0.85, 95% CI 0.68-1.06; p = 0.141) and a positive trend for...
Particulate matter composition and respiratory health: the PIAMA birth cohort study (Publications)
potassium, nickel, sulfur, silicon, vanadium, and zinc in particles with diameters of less than 2.5 and 10 mum (PM2.5 and PM10) at birth addresses and current addresses from land-use regression models. Exposure-health [...] address. Forced expiratory volume in 1 second was negatively associated with copper and iron in PM2.5 (change [95% confidence interval] -2.1% [-1.1, -0.1%] and -1.0% [-2.0, -0.0%]) and FEF75-50 with copper
Spatial and temporal distribution of soil-transmitted helminth infection in sub-Saharan Africa: a systematic review and geostatistical meta-analysis (Publications)
lumbricoides, and T trichiura over a grid of roughly 1 million pixels at a spatial resolution of 5?×?5 km. We calculated anthelmintic treatment needs on the basis of WHO guidelines (treatment of all s [...] prevalence of hookworm, A lumbricoides, and T trichiura among school-aged children from 2000 onwards was 16·5%, 6·6%, and 4·4%. These estimates are between 52% and 74% lower than those in surveys done before 2000
Single-center outcome analysis of 1,161 patients with St. Jude medical and ATS open pivot mechanical heart valves (Publications)
family physicians. Follow up was 98.9% complete; the median follow up was 4.6 years; total follow up was 5,624 patient-years (pt-yr). RESULTS: A total of 604 SJM and 601 ATS prostheses was implanted as isolated [...] freedom from valve-related mortality at 10 years for SJM and ATS valves were 66 +/- 3% versus 68 +/- 5% (p = 0.84) and 96 +/- 1% versus 97 +/- 1% (p = 0.36), respectively. No structural valve failure was [...] respectively, were: thromboembolism 0.9 and 1.1%/pt-yr; major bleeding...
Schistosomiasis in infants and preschool-aged children: infection in a single <em>Schistosoma haematobium</em> and a mixed <em>S. haematobium - S.... (Publications)
haematobium infections among young children and their mothers was respectively 50.5% and 55.6%, in Falmado, and 60.5% and 72.2% in Diambala. The prevalence of S. mansoni infection in Diambala was 43.8% [...] canals to wash their children. To conclude, a substantive proportion of children below the age of 5 years had egg-patent schistosomiasis, inclusive of co-infection with S. haematobium and S. mansoni.
