A population-based study on the implementation of treatment recommendations for chemotherapy in early breast cancer (Publications)
receptor (ER) status (OR, 3.8; 95% CI, 2.6-5.5), human epidermal growth factor receptor 2 (HER2) status (OR, 1.9; 95% CI, 1.3-2.7), and patient age (OR, 4.6; 95% CI, 3.5-6.2) were less important predictors for
Seasonal malaria chemoprevention and the spread of <em>Plasmodium falciparum </em>quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a... (Publications)
monthly cycles to children aged 3 months to 5 years (with 95% initial coverage declining each cycle), the quintuple mutant required 53·1 years (95% CI 50·5-56·0) to spread from 1% to 50% of inoculations [...] yrimethamine plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region. However, Plasmodium falciparum parasites partially resistant to sul
Prevalence and predictors of residual antibiotics in children's blood in community settings in Tanzania (Publications)
detected antibiotics were trimethoprim (144/1699; 8.5%), sulfamethoxazole (102/1699; 6.0%), metronidazole (61/1699; 3.6%) and amoxicillin (43/1699; 2.5%). The strongest predictors of residual antibiotics [...] home (aOR=2.9; 95% CI: 2.0-4.1) and reported consumption of antibiotics in the last two weeks (aOR=2.5; 95% CI: 1.6-3.9). However, half (145/296) of the children who had residual antibiotics in their blood
Investigation of antiplasmodial effects of terpenoid compounds isolated from myrrh (Publications)
lide (4: ), 2-methoxyisogermafurenolide (5: ), 8-epi-2-methoxyisogermafurenolide (6: ), furanodienone (7: ), 1(10)Z,4Z-furanodien-6-one (8: ), rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one [...] compounds were identified by MS and NMR spectroscopic analyses. To the best of our knowledge, compounds 5, 6, 12, 13, 16, 18: , and 20: are reported for the first time. All isolated compounds were tested in
Burden and risk factors of suspected cholangiocarcinoma in high <em>Opisthorchis viverrini</em> endemic rural communities in southern Lao PDR (Publications)
associated with OV infection (adjusted odds ratio [aOR] 3.4, 95% CI 1.7-6.5), and a history of cholecystectomy (aOR 2.7, 95% CI 1.5-4.9). CONCLUSION: Our CCA screening in high OV prevalence rural areas of [...] 400 participants, the overall prevalence of suspected CCA was 7.2% (95% confidence interval [95% CI] 5.4-9.6). The suspected CCA prevalence increased with age, and was higher in men at all ages. Almost all
Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance (Publications)
acquired drug resistance was 3.2% (2.8,3.5) for immediate initiation, 3.1% (2.7,3.3) for initiation with CD4 cell count less than 500 cells/mul, and 2.8% (2.5,3.0) for initiation with CD4 cell count less [...] restricted to individuals with baseline in 2005-2015, the corresponding estimates were 1.9% (1.8, 2.5), 1.9% (1.7, 2.4), and 1.8% (1.7, 2.2). CONCLUSION: Our findings suggest that the risk of acquired drug
Germline Elongator mutations in Sonic Hedgehog medulloblastoma (Publications)
genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children(1,2), and genetic events that cooperate with known somatic driver [...] Pathogenic germline variants in established cancer predisposition genes have been recently identified in 5% of patients with the malignant brain tumour medulloblastoma(3). Here, by analysing all protein-coding [...] which catalyses translational elongation through tRNA modifications...
Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts (Publications)
Respiratory Health Survey) were included. Annual exposure to NO2, PM10, PM2.5, and PMcoarse (calculated by subtracting PM2.5 from PM10) was estimated using land-use regression models derived from the European [...] moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM2.5. Higher exposure to NO2 was associated with an increased severity of rhinitis, with similar adjusted
Molecular detection of <em>Rickettsia </em>spp., <em>Borrelia </em>spp., <em>Bartonella </em>spp. and <em>Yersinia pestis</em> in ectoparasites of... (Publications)
with fleas. Borrelia spp. were detected in 5% of H. simplex and 1% of R. microplus ticks. Bartonella spp. were detected in 40% of H. quadripertusus pools and in 5% of L. verruculosus pools. Y. pestis was [...] adjacent littoral region. Thirteen species of blood-feeding ectoparasites (235 individuals of ticks [5 species], 414 lice [4 spp.] and 389 fleas [4 spp.]) were investigated for the presence and identity
Risk factors for the carriage of<em> Streptococcus infantarius </em>subspecies <em>infantarius </em>isolated from African fermented dairy products (Publications)
prevalence of SBSEC and Sii carriage was 23.2% (confidence interval CI 95% = 18.9-27.5) and 12.0% (CI 95% = 8.4-15.5) for stool, respectively. Prevalence of Sii was significantly higher in consumers of [...] as in persons handling livestock (OR = 3.9; 95% CI = 1.6-9.3) and livestock primary products (OR = 5.7; 95% CI = 2.3-14.3). The closer contact with livestock was a risk factor for Sii fecal carriage. Sii