Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering (Publications)
with synchrotron phase contrast X-ray microtomography. Mini-tablets had a weight of 9.5 mg and a drug load from 2.5% to 20%. Moxidectin, a drug used for treatment of parasitic infections, was used as a
In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants (Publications)
with IC50 values of 1.0 mu g/ml and 0.2 mu g/ml, respectively. Five extracts showed IC50 values below 5 mu g/ml against Leishmania donovani, with the methanolic seed extract of Harungana madagascarensis showing [...] extract of Albizia zygia showed the best ratio of cytotoxicity to antitrypanosomal activity (SIb = 22.5). (c) 2006 Elsevier Ireland Ltd. All rights reserved
The essential malaria protein <em>Pf</em>CyRPA targets glycans to invade erythrocytes (Publications)
glycans terminating with α2-6-linked N-acetylneuraminic acid (Neu5Ac). PfCyRPA has a > 50-fold binding preference for human, α2-6-linked Neu5Ac over non-human, α2-6-linked N-glycolylneuraminic acid. PfCyRPA
Improved latrines minimally impact <em>Schistosoma mekongi </em>transmission in Mekong islands (Publications)
follows: Opisthorchis viverrini, 79.5% and 71.8%; hookworm, 48.8% and 65.6%; and Strongyloides stercoralis, 43.1% and 38.3%. Other helminth species were detected in less than 5% of the study participants. Latrine
Implementing focused echocardiography and AI-supported analysis in a population-based survey in Lesotho: implications for community-based... (Publications)
confirmed by a cardiologist. Of the 126 not evaluable by the AI algorithm, 46 (36.5%) were manually evaluable. Overall, 660 (87.5%) uploaded files were evaluable and confirmed. Following short-term training
Time to harmonize national ambient air quality standards (Publications)
inventory of ambient air quality standards for 194 countries worldwide for six air pollutants: PM2.5, PM10, ozone, nitrogen dioxide, sulphur dioxide and carbon monoxide. We conducted literature and internet [...] standards. Levels varied greatly by country and by pollutant. Ambient air quality standards for PM2.5, PM10 and SO2 poorly complied with WHO guideline values. The agreement was higher for CO, SO2 (10-min
A multi-band body-worn distributed exposure meter for personal radio-frequency dosimetry in diffuse indoor environments (Publications)
measurement uncertainty with a 68% confidence interval on its antenna apertures, in the range 3.4-5.5 dB. A maximum difference of 0.9 dB is obtained for the total exposure in the test areas between the
Cholesterol metabolites exported from human brain (Publications)
2-3mg/24h. Gas chromatography (GC)-MS data shows that the cholesterol metabolites 5alpha-hydroxy-6-oxocholesterol (3beta,5alpha-dihydroxycholestan-6-one), 7beta-hydroxycholesterol and 7-oxocholesterol, generally
Comparison of sensitivity and annoyance to road traffic and community noise between a South African and a Swiss population sample (Publications)
highly noise sensitive individuals (women: 35.1% vs 26.9%; men: 25% vs 20.5%) and people highly annoyed to road traffic noise (women: 20.5% vs 12.4%; men: 17.9% vs 11.1%) were observed in South Africa. While
<em>Plasmodium vivax</em> and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea (Publications)
anaemia [haemoglobin < 5 g/dl]). Out of 17,201 presumptive malaria cases, 9,537 (55%) had a confirmed Plasmodium parasitaemia. Among those, 6.2% (95% confidence interval [CI] 5.7%-6.8%) fulfilled the case