Genetic diversity of <em>Mycobacterium tuberculosis</em> in Madang, Papua New Guinea (Publications)
tuberculosis were observed in 5.2% of isolates. Lineage 2 M. tuberculosis, which includes the 'Beijing' genotype, was significantly associated with any drug resistance (OR 5.2, 95%CI 1.8-15.1). Cluster analyses
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles (Publications)
anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamide derivatives, which proved to be active against replicating
Antiparasitic compounds from <em>Cupania cinerea</em> with activities against <em>Plasmodium falciparum</em> and <em>Trypanosoma brucei... (Publications)
moiety named cupacinoxepin (3), together with the known compounds scopoletin (4), caryophyllene oxide (5), two bisabolane sesquiterpenes (6 and 7), lichexanthone (8), gustastatin (9), lupenone (10), betulone [...] the P. falciparum K1 strain (IC(50)1, 1.3; 2, 1.8; and 3, 8.7 muM) and T. b. rhodesiense (IC(50)1, 4.5; 2, 15.8; and 3, 71.6 muM) were found. Cytotoxicity toward L-6 cells is discussed for all the compounds
Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: The Protection against Allergy-Study in Rural... (Publications)
mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha. RESULTS: Allergen-specific IgE antibodies were detectable in 23.9% [...] soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10. CONCLUSION: Allergen-specific IgE antibodies most probably of fetal origin are detectable
In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants (Publications)
with IC50 values of 1.0 mu g/ml and 0.2 mu g/ml, respectively. Five extracts showed IC50 values below 5 mu g/ml against Leishmania donovani, with the methanolic seed extract of Harungana madagascarensis showing [...] extract of Albizia zygia showed the best ratio of cytotoxicity to antitrypanosomal activity (SIb = 22.5). (c) 2006 Elsevier Ireland Ltd. All rights reserved
Genetic diversity of <em>Mycobacterium tuberculosis</em> in Madang, Papua New Guinea (Publications)
tuberculosis were observed in 5.2% of isolates. Lineage 2 M. tuberculosis, which includes the 'Beijing' genotype, was significantly associated with any drug resistance (OR 5.2, 95%CI 1.8-15.1). Cluster analyses
Seroepidemiological study of African horse sickness virus in The Gambia (Publications)
AHSV; this consisted of 18% (of the total number of serum samples) strongly positive, 46.5% moderately positive, and 16.5% weakly but still clearly positive. Such results suggest a high prevalence of AHSV in
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles (Publications)
anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamide derivatives, which proved to be active against replicating
<em>Plasmodium vivax</em> and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea (Publications)
anaemia [haemoglobin < 5 g/dl]). Out of 17,201 presumptive malaria cases, 9,537 (55%) had a confirmed Plasmodium parasitaemia. Among those, 6.2% (95% confidence interval [CI] 5.7%-6.8%) fulfilled the case
Antiparasitic compounds from <em>Cupania cinerea</em> with activities against <em>Plasmodium falciparum</em> and <em>Trypanosoma brucei... (Publications)
moiety named cupacinoxepin (3), together with the known compounds scopoletin (4), caryophyllene oxide (5), two bisabolane sesquiterpenes (6 and 7), lichexanthone (8), gustastatin (9), lupenone (10), betulone [...] the P. falciparum K1 strain (IC(50)1, 1.3; 2, 1.8; and 3, 8.7 muM) and T. b. rhodesiense (IC(50)1, 4.5; 2, 15.8; and 3, 71.6 muM) were found. Cytotoxicity toward L-6 cells is discussed for all the compounds