China's sustained drive to eliminate neglected tropical diseases (Publications)
and viruses. Lymphatic filariasis was eliminated in 2007, but schistosomiasis still affects up to 5% of local village residents in some endemic counties with around 300 000 people infected. China harbours [...] Corresponding figures for food-borne trematodiasis, echinococcosis, and cysticercosis are more than 5%. Dengue, leishmaniasis, leprosy, rabies, and trachoma exist in many areas and should not be overlooked
Antiparasitic compounds from <em>Cupania cinerea</em> with activities against <em>Plasmodium falciparum</em> and <em>Trypanosoma brucei... (Publications)
moiety named cupacinoxepin (3), together with the known compounds scopoletin (4), caryophyllene oxide (5), two bisabolane sesquiterpenes (6 and 7), lichexanthone (8), gustastatin (9), lupenone (10), betulone [...] the P. falciparum K1 strain (IC(50)1, 1.3; 2, 1.8; and 3, 8.7 muM) and T. b. rhodesiense (IC(50)1, 4.5; 2, 15.8; and 3, 71.6 muM) were found. Cytotoxicity toward L-6 cells is discussed for all the compounds
Genetic diversity of <em>Mycobacterium tuberculosis</em> in Madang, Papua New Guinea (Publications)
tuberculosis were observed in 5.2% of isolates. Lineage 2 M. tuberculosis, which includes the 'Beijing' genotype, was significantly associated with any drug resistance (OR 5.2, 95%CI 1.8-15.1). Cluster analyses
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles (Publications)
anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamide derivatives, which proved to be active against replicating
Time to harmonize national ambient air quality standards (Publications)
inventory of ambient air quality standards for 194 countries worldwide for six air pollutants: PM2.5, PM10, ozone, nitrogen dioxide, sulphur dioxide and carbon monoxide. We conducted literature and internet [...] standards. Levels varied greatly by country and by pollutant. Ambient air quality standards for PM2.5, PM10 and SO2 poorly complied with WHO guideline values. The agreement was higher for CO, SO2 (10-min
A multi-band body-worn distributed exposure meter for personal radio-frequency dosimetry in diffuse indoor environments (Publications)
measurement uncertainty with a 68% confidence interval on its antenna apertures, in the range 3.4-5.5 dB. A maximum difference of 0.9 dB is obtained for the total exposure in the test areas between the
Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering (Publications)
with synchrotron phase contrast X-ray microtomography. Mini-tablets had a weight of 9.5 mg and a drug load from 2.5% to 20%. Moxidectin, a drug used for treatment of parasitic infections, was used as a
The essential malaria protein <em>Pf</em>CyRPA targets glycans to invade erythrocytes (Publications)
glycans terminating with α2-6-linked N-acetylneuraminic acid (Neu5Ac). PfCyRPA has a > 50-fold binding preference for human, α2-6-linked Neu5Ac over non-human, α2-6-linked N-glycolylneuraminic acid. PfCyRPA
Implementing focused echocardiography and AI-supported analysis in a population-based survey in Lesotho: implications for community-based... (Publications)
confirmed by a cardiologist. Of the 126 not evaluable by the AI algorithm, 46 (36.5%) were manually evaluable. Overall, 660 (87.5%) uploaded files were evaluable and confirmed. Following short-term training
Improved latrines minimally impact <em>Schistosoma mekongi </em>transmission in Mekong islands (Publications)
follows: Opisthorchis viverrini, 79.5% and 71.8%; hookworm, 48.8% and 65.6%; and Strongyloides stercoralis, 43.1% and 38.3%. Other helminth species were detected in less than 5% of the study participants. Latrine