Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African... (Publications)
gene, Vgsc). The putative associations were confirmed for two of the marker SNPs, in the P450 Cyp4j5 and the esterase Coeae1d by reproducible association with pyrethroid resistance in multiple field c [...] also showed evidence of association with resistance as did environmental humidity. Sequencing of Cyp4j5 and Coeae1d detected no resistance-linked loss of diversity, suggesting selection from standing variation
Isolation and structural elucidation of compounds from <em>Pleiocarpa bicarpellata</em> and their <em>in vitro</em> antiprotozoal activity (Publications)
falciparum (IC50 value of 3.5 microg/mL). Among the compounds isolated, tubotaiwine (13) displayed the most significant antiplasmodial activity with an IC50 value of 8.5 microM and a selectivity index
An intra-COVID-19 assessment of hand hygiene facility, policy and staff compliance in two hospitals in Sierra Leone: is there a difference between... (Publications)
capital city (17.0%) hospitals. The HH levels for the capital city and regional hospitals were 277.5 and 262.5 respectively. Despite the COVID-19 pandemic, there are still challenges with HH compliance in Sierra
Whole genome sequencing and spatial analysis identifies recent tuberculosis transmission hotspots in Ghana (Publications)
and ArcGIS. Of the 452 traditional genotype clustered genomes, 314 (69.5%) were confirmed clusters with a median cluster size of 7.5 genomes and an interquartile range of 4-12. Recent tuberculosis (TB)
Estimated population-level impact of pneumococcal conjugate vaccines against all-cause pneumonia mortality among unvaccinated age groups in five Latin... (Publications)
aimed to assess the population-level impact of pediatric PCVs on all-cause pneumonia mortality among ≥5 years of age, and invasive pneumococcal disease (IPD) cases in Chile. METHODS: Demographic and mortality [...] mortality data from Argentina, Brazil, Chile, Colombia, and Mexico were collected considering the ≥ 5-year-old population, from 2000-2019, with 1,795,789 deaths due to all-cause pneumonia. IPD cases in Chile
Pathways and associated costs of care in patients with confirmed and presumptive tuberculosis in Tanzania: a cross-sectional study (Publications)
presumptive patients did so at hospitals. The median visits made by confirmed patients was 2 (range 1-5) and 2 (range 1-3) by presumptive patients. Patients spent a median of 31% of their monthly household [...] [IQR 18.7-48.4] vs USD 19.8 [IQR 13.8-34.0], p=0.02), as were the indirect costs (USD 66.9 [IQR 35.5-150.0] vs USD 46.8 [IQR 20.1-115.3], p
Testing bio-efficacy of insecticide-treated nets with fewer mosquitoes for enhanced malaria control (Publications)
alternative protocol, using fewer mosquitos, while ensuring a precision in the main indicator of +/-5 percentage points (pp). We compared different laboratory methods against the probability of the LLIN [...] proportion of nets considered as valid was 0.40 pp. The 95% confidence interval of this value never exceed 5 pp when the number of LLIN tested was > /=40. This method slightly outperforms the current recommendations
Development of land use regression models for elemental, organic carbon, PAH and hopanes/steranes in 10 ESCAPE/TRANSPHORM European study areas (Publications)
aromatic hydrocarbons (PAH), hopanes/steranes and elemental and organic carbon (EC/OC) content of PM2.5. In 10 European study areas PAH, hopanes/steranes and EC/OC concentrations were measured at 16-40 sites [...] The moderate to high explained variance of LUR models and the overall moderate correlation with PM2.5 model predictions support the application of especially the OC and PAH models in epidemiological studies
Simulation of population-based commuter exposure to NO2 using different air pollution models (Publications)
range: 21-61) than with a dispersion model with a lower resolution (39 ± 5 µg m-3; range: 24-51), and a land use regression model (41 ± 5 µg m-3; range: 24-54). Highest median cumulative exposures were calculated
Effects of scale, question location, order of response alternatives, and season on self-reported noise annoyance using ICBEN scales: a field... (Publications)
of a balanced experimental design, the effect of type of annoyance question and corresponding scale (5-point verbal vs. 11-point numerical ICBEN (International Commission on Biological Effects of Noise) [...] 11-point numerical scale whereas the percentage of highly annoyed respondents was higher based on the 5-point scale, using common cutoff points. In conclusion, placement and presentation of annoyance questions
