Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against <em>Schistosoma mansoni </em>and <em>Schistosoma... (Publications)
in mice. Subsequently, a ruthenocenyl (5) and a benzyl derivative (6) of OXA were synthesized to probe the importance of the ferrocenyl group in 1. Compounds 1, 5, and 6 were lethal to both S. mansoni and
Prevention of mother-to-child transmission of HIV Option B+ cascade in rural Tanzania: the one stop clinic model (Publications)
RESULTS: 1,579 women attended the ANC. Seven (0.4%) were known to be HIV-infected. Of the remainder, 98.5% (1,548/1,572) were offered an HIV test, 94% (1,456/1,548) accepted and 38 (2.6%) tested HIV-positive [...] during both the pre- and post-B+ periods. During the post-B+ period, test acceptance (94% versus 90.5%, p
Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study (Publications)
definitions as reference standard. RESULTS: In total, 215 children were included. The median age was 5.4 years, the HIV prevalence was 52% and 13% had culture-confirmed pulmonary tuberculosis. When only [...] of Xpert Ultra was 64.3 % (95% CI: 44.1 to 81.4) while that of Xpert was 53.6% (95%CI: 33.9 to 72.5). The specificity of Xpert Ultra based on analysis of all available samples was 98.1% (95%CI: 93.4 to
Occurrence and duration of various operational definitions of sedentary bouts and cross-sectional associations with cardiometabolic health indicators:... (Publications)
sedentary time in bouts of > /=5min while bouts of > /=20min were rare. Linear regression analysis revealed few significant associations of sedentary time accumulated in bouts of > /=5-30min with health indicators
Health effects of the 2003 Southern California wildfires on children (Publications)
17-18 yr) and elementary-school children (n = 5,551; age, 6-7 yr), in a total of 16 communities. Estimates of particulate matter (PM10) concentrations during the 5 d with the highest fire activity were used
Evaluation of <em>Plasmodium vivax</em> genotyping markers for molecular monitoring in clinical trials (Publications)
capillary electrophoresis to determine the extent of size polymorphism for 9 potential genetic markers (5 genes of merozoite surface proteins [msp] and 4 microsatellites) in 93-108 P. vivax-positive blood samples [...] respectively, followed by 2 fragments of msp1 and 2 other microsatellites. msp3alpha, msp4, and msp5 revealed limited polymorphism. CONCLUSIONS: Even for the most diverse markers, the highest allelic
Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae (Publications)
rhodesiense, with Corallina officinalis and Ceramium virgatum being the most potent (IC(50) values 4.8 and 5.4 mug/ml), whilst none of the algal extracts inhibited the growth of T. cruzi. Except for Porphyra [...] extracts from all seaweeds also showed leishmanicidal activity with IC(50) values ranging from 16.5 to 85.6 mug/ml. Only the crude extract of Calliblepharis jubata showed some weak activity against M
Low risk for transmission of zoonotic <em>Giardia duodenalis</em> from dogs to humans in rural Cambodia (Publications)
characterisation of the glutamate dehydrogenase (gdh) gene placed 27.5% (11/40) of Giardia positive humans into assemblage AII and 72.5% (29/40) into assemblage BIII of G. duodenalis. In dogs, 20.0% (2/10)
Improved outcome for very low birth weight multiple births (Publications)
8 (11.7) to 96.5 (18.6), analysis of covariance P = 0.007. The prevalence of cerebral palsy decreased, however not significantly adjusted odds ratio (95% confidence interval) 0.3 (0.1-1.5), P = 0.14. The
Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against <em>Plasmodium falciparum</em> in Papua New... (Publications)
A phase I-IIb double-blind randomised placebo-controlled trial was undertaken in 120 children aged 5-9 years. Subjects were randomised in four groups: (i) No sulphadoxine-pyrimethamine (SP)+vaccine, (ii) [...] vaccine group where No SP had been given.Combination B proved to be safe and immunogenic in children aged 5-9 years. Vaccine immunogenicity was neither impaired by circulating parasites nor increased after p