1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as [...] European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 x 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2
Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against <em>Schistosoma mansoni </em>and <em>Schistosoma... (Publications)
in mice. Subsequently, a ruthenocenyl (5) and a benzyl derivative (6) of OXA were synthesized to probe the importance of the ferrocenyl group in 1. Compounds 1, 5, and 6 were lethal to both S. mansoni and
Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae (Publications)
rhodesiense, with Corallina officinalis and Ceramium virgatum being the most potent (IC(50) values 4.8 and 5.4 mug/ml), whilst none of the algal extracts inhibited the growth of T. cruzi. Except for Porphyra [...] extracts from all seaweeds also showed leishmanicidal activity with IC(50) values ranging from 16.5 to 85.6 mug/ml. Only the crude extract of Calliblepharis jubata showed some weak activity against M
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
confounders and stratified by sex and allergic sensitisation at baseline.Over 20 years, 128 (5.1%) men and 198 (7.5%) women newly reported doctor-diagnosed asthma. The adjusted odds ratio for female sex was
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study... (Publications)
patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular
<em>SERPINA1</em> gene variants in individuals from the general population with reduced {alpha}1-antitrypsin concentrations (Publications)
Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) with serum AAT concentrations 5 sequencing. RESULTS: We found that 900 of 1399 samples (64%), carried the normal PI*MM genotype, whereas [...] 103 to 113 and from 93 to 103 mg/dL, individuals with the PI*MM genotype represented the majority (86.5% and 53.8%, respectively). The PI*MS genotype was predominant (54.9%) in the AAT range of 83 to 93 mg/dL
Identification of a new locus at 16q12 associated with time-to-asthma onset (Publications)
performed by using survival analysis techniques. RESULTS: We detected 5 regions associated with TAO at the genome-wide significant level (P < 5 x 10-8). We evidenced a new locus in the 16q12 region (near cyl
Health effects of the 2003 Southern California wildfires on children (Publications)
17-18 yr) and elementary-school children (n = 5,551; age, 6-7 yr), in a total of 16 communities. Estimates of particulate matter (PM10) concentrations during the 5 d with the highest fire activity were used
<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
using a single bolus dose for administration. Total cure in mice was seen at single i.p. doses of 5 and 2.5 mg/kg, for T. congolense- and T. vivax-infected mice, respectively. This study identified a selection
Ealamines A-H, a series of naphthylisoquinolines with the rare 7,8'-coupling site, from the Congolese liana <em>Ancistrocladus ealaensis</em>,... (Publications)
naphthylisoquinoline alkaloids were isolated, comprising eight new compounds, named ealamines A-H (4a, 4b, 5-10), and two known ones, 6-O-demethylancistrobrevine A (11) and yaoundamine A (12), which had previously [...] nutrient-deprived medium, without causing toxicity under normal, nutrient-rich conditions, with ealamine C (5) as the most potent agent.