Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study... (Publications)
patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
confounders and stratified by sex and allergic sensitisation at baseline.Over 20 years, 128 (5.1%) men and 198 (7.5%) women newly reported doctor-diagnosed asthma. The adjusted odds ratio for female sex was
<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
using a single bolus dose for administration. Total cure in mice was seen at single i.p. doses of 5 and 2.5 mg/kg, for T. congolense- and T. vivax-infected mice, respectively. This study identified a selection
Identification of a new locus at 16q12 associated with time-to-asthma onset (Publications)
performed by using survival analysis techniques. RESULTS: We detected 5 regions associated with TAO at the genome-wide significant level (P < 5 x 10-8). We evidenced a new locus in the 16q12 region (near cyl
Airborne particle exposure and extrinsic skin aging (Publications)
signs, in particular to pigment spots and less pronounced to wrinkles. An increase in soot (per 0.5 x 10(-5) per m) and particles from traffic (per 475 kg per year and square km) was associated with 20% more
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as [...] European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 x 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2
Size-resolved emissions of organic tracers from light- and heavy-duty vehicles measured in a California roadway tunnel (Publications)
generated via combustion. Most efforts to date have focused on emissions and apportionment PM10 or PM2.5 However, examining how these compounds are segregated by particle size in both emissions and ambient [...] markers apportioned to diesel and gasoline vehicles. The results are compared to previously conducted PM2.5 emissions testing using dynamometer facilities and othertunnel environments
Leishmanicidal cycloartane-type triterpene glycosides from <em>Astragalus oleifolius</em> (Publications)
Three known cycloartane glycosides cyclocanthoside E (3), astragaloside II (4) and astragaloside IV (5) were also isolated and characterized. All five compounds were evaluated for in vitro trypanocidal, [...] activities as well as their cytotoxic potential on primary mammalian (L6) cells. Except for the compound 5, all compounds showed notable growth inhibitory activity against Leishmania donovani with IC50 values
Water quality, sanitation, and hygiene conditions in schools and households in Dolakha and Ramechhap districts, Nepal: results from a cross-sectional... (Publications)
school drinking water source samples and 76.9% point-of-use samples (water bottles) at schools, 39.5% water source samples in the community, and 27.4% point-of-use samples at household levels were contaminated [...] t coliforms. The values of water samples for pH (6.8-7.6), free and total residual chlorine (0.1-0.5 mg/L), mean lead concentration (0.01 mg/L), and mean arsenic concentration (0.05 mg/L) were within national
Evaluation of <em>Plasmodium vivax</em> genotyping markers for molecular monitoring in clinical trials (Publications)
capillary electrophoresis to determine the extent of size polymorphism for 9 potential genetic markers (5 genes of merozoite surface proteins [msp] and 4 microsatellites) in 93-108 P. vivax-positive blood samples [...] respectively, followed by 2 fragments of msp1 and 2 other microsatellites. msp3alpha, msp4, and msp5 revealed limited polymorphism. CONCLUSIONS: Even for the most diverse markers, the highest allelic
