Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height (Publications)
surpassing the conventional genome-wide significance threshold (p < 5 x 10(-8)). Common variants with minor allele frequencies greater than 5% were observed to be associated with height in 37 previously reported
Prevalence and time course of acute mountain sickness in older children and adolescents after rapid ascent to 3450 meters (Publications)
which was reached through a 2.5-hour train ascent. RESULTS: We found that the overall prevalence of acute mountain sickness during the first 3 days at high altitude was 37.5%. Rates were similar for the
Predictors and overestimation of recalled mobile phone use among children and adolescents (Publications)
duration of calls was not significantly different for controls compared to cases (OR=1.1, 95%-CI: 0.5 to 2.5 and OR=1.9, 95%-CI: 0.85 to 4.3, respectively). However, likelihood to overestimate was associated
Analysis of <em>Plasmodium falciparum</em> infections in a village community in Northern Nigeria: determination of msp2 genotypes and parasitespecific... (Publications)
of the rainy season, when transmission is high. We analysed blood samples from 104 individuals aged 5-70 years by polymerase chain reaction (PCR) amplifying the gene for the merozoite surface protein MSP2 [...] afterwards decreased significantly with age. Mean multiplicity in those 8-10-year-old children was 5.4 clones per carrier. Peak multiplicity and parasite diversity in Nigerian individuals is compared to
Bayesian risk mapping and model-based estimation of <em>Schistosoma haematobium </em>- <em>Schistosoma mansoni</em> co-distribution in Côte... (Publications)
from a national, cross-sectional survey conducted between November 2011 and February 2012. More than 5,000 children in 92 schools across Cote d'Ivoire participated. Bayesian geostatistical multinomial models [...] FINDINGS: We estimated that 8.9% of school-aged children in Cote d'Ivoire are affected by schistosomiasis; 5.3% with S. haematobium and 3.8% with S. mansoni. Approximately 2 million annualized praziquantel treatments
Diarrhoea, vomiting and the role of milk consumption: perceived and identified risk in Bamako (Mali) (Publications)
toxi-infections with diarrhoea and vomiting as main clinical picture. A total of 131 schoolchildren between 5 and 20 years of age were interviewed by trained interviewers in schools in Bamako. A structured que [...] identified regular consumption of boiled milk [odds ratio(OR) = 4.38; 95% CI = 1.15-16.71], age between 5 and 10 years (OR vs. age group 11-15 years = 3.28; 95% CI = 1.09-9.85) and the existence of dry latrines
Changes in active and passive smoking in the European Community Respiratory Health Survey (Publications)
adjusted hazard risk ratio (HRR) or odds ratio (OR). The prevalence of active smoking declined by 5.9% (5.1-6.8) and exposure to passive smoking in nonsmokers declined by 18.4% (16.8-20.0). Subjects with
Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with <em>Fasciola hepatica</em> in sheep (Publications)
t(max) were 13.7+/-6.1mug/ml and 0.9+/-0.4h, respectively. The alpha and beta half-lives were 4.5+/-4.3h and 56.5+/-36h, respectively and the mean AUC was 219.1+/-74mugmin/ml. Further studies are needed to
Discovery of dual function acridones as a new antimalarial chemotype (Publications)
administration, inexpensive synthesis and favourable physicochemical properties), our initial lead, T3.5 (3-chloro-6-(2-diethylamino-ethoxy)-10-(2-diethylamino-ethyl)-acridone), demonstrates unique synergistic [...] -like' chemosensitization to chloroquine and amodiaquine against quinoline-resistant parasites, T3.5 also results in an apparently mechanistically distinct synergism with quinine and with piperaquine.
Blood-stage parasitaemia and age determine <em>Plasmodium falciparum</em> and <em>P. vivax</em> gametocytaemia in Papua New Guinea (Publications)
reverse-transcriptase PCR (qRT-PCR). The parasite prevalence by PCR was 18.5% for Plasmodium falciparum and 13.0% for P. vivax. 52.5% of all infections were submicroscopic. Gametocytes were detected in 60%