Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment (Publications)
22-45 days) after drug administration. PRINCIPAL FINDINGS: The 13 studies enrolled 5,759 STH stool-positive individuals; 5,688 received active medication or placebo contributing a total of 11,103 STH infections [...] tions 775 (23%). The overall mean ERR assessed by day 14-21 for albendazole and mebendazole was 94.5% and 87.4%, respectively on Ascaris lumbricoides, 86.8% and 40.8% on hookworm, and 44.9% and 23.8% on
Acquired HIV drug resistance among adults living with HIV receiving first-line antiretroviral therapy in Rwanda: a cross-sectional nationally... (Publications)
4%) non-nucleoside reverse transcriptase inhibitor- (NNRTI), 291 (75.5%) nucleoside reverse transcriptase inhibitor- (NRTI) and 13 (3.5%) protease inhibitor (PI) resistance-associated mutations. The most [...] History of ever switching ART regimen was associated with NRTI resistance (aOR, 2.53 [95% CI: 1.198-5.356]; p = 0.016) and NNRTI resistance (aOR, 3.23 [95% CI: 1.435-7.278], p = 0.005). CONCLUSION: The
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of <em>Plasmodium falciparum</em> malaria (Publications)
s in rats at 100 mg/kg body weight shows good exposures (Cmax = 1.1 microM) and half-life (T1/2 = 5.5 h). Furthermore, a 14-day toxicokinetic study at 100 mg/kg daily dose did not show any abnormality [...] gametocytes, indicating a potential for transmission control: IC50 values being 190 nM for male and > 5 microM for female gametocytes. FNDR-20123 is a stable candidate in human/mouse/rat liver microsomes
Cross-reaction of POC-CCA urine test for detection of <em>Schistosoma mekongi</em> in Lao PDR: a cross-sectional study (Publications)
(predictors) with POC-CCA test results (outcome). RESULTS: In S. mekongi-endemic Champasack, 11.5% (n = 366) and 0.5% (n = 2) of study participants had positive POC-CCA and Kato-Katz test results, respectively [...] is not endemic, the POC-CCA test yielded (presumably) false positive results for 6.0% (n = 22) and 2.5% (n = 9) of study participants, respectively, while all of the Kato-Katz tests were negative. POC-CCA
Intestinal helminth infections and associated risk factors among adults in the Lao People's Democratic Republic (Publications)
participants were enrolled. Their average age was 46.0 years; 57.8% were female. Overall, 30.9%, 8.6% and 1.5% of study participants were infected with one, two, or three different intestinal helminth species, [...] viverrini-like (Ov-like) infection, 4.8% with Strongyloides stercoralis, 2.3% with Ascaris lumbricoides, 1.5% with Trichuris trichiura, and 3.3% with Taenia spp. Ov-like infection was of high prevalence in the [...] infected with hookworm [adjusted odds ratio (aOR) = 1.2, P = 0.019]....
Efficacy and safety of moxidectin compared with ivermectin against <em>Strongyloides stercoralis</em> infection in adults in Laos and Cambodia: a... (Publications)
in the ivermectin group, resulting in a between-group difference of -2·1 percentage points (95% CI -5·5 to 1·3). The most common adverse events were abdominal pain (32 [9%] of 363 with moxidectin vs 34 [9%] [...] (n=363). For the participants with primary outcome data, we observed a cure rate of 93·6% (95% CI 90·5 to 96·0; 324 of 346 participants) in the moxidectin group and 95·7% (93·0 to 97·6; 335 of 350 participants)
Evaluation of tuberculosis diagnostic test accuracy using Bayesian latent class analysis in the presence of conditional dependence between the... (Publications)
screen for PTB: any TB symptom, radiologist conclusion, Computer Aided Detection for TB version 5 (CAD4TBv5> /=53), CAD4TBv6> /=53, Xpert Ultra (excluding trace) and culture. Before the application of our [...] CrI: 48.7, 74.4) and 75.9% (95% CrI: 61.9, 89.2), respectively. Any chest X-ray abnormality, CAD4TBv5> /=53 and CAD4TBv6> /=53 had similar overall sensitivity. Up to 73.3% (95% CrI: 61.4, 83.4) of all true
Access to vaccination services for priority ruminant livestock diseases in Ghana: barriers and determinants of service utilization by farmers (Publications)
convergence across the different datasets and analyses. RESULTS: The farmers kept an average (median) of 5 tropical livestock units (TLUs) of ruminant livestock (IQR=2.6-12.0) that were on average 8 kilometers [...] reported experiencing outbreaks of either disease in the study year (2021). Farmers scored on average 80.5 out of 98 (IQR=74-85) on the RS-14 resilience scale. After adjusting for farmers' livestock rearing [...] 95%CI=0.08-0.43), and positively associated with personal exposure to...
Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood (Publications)
9.2%] and early persistent [n = 67; 6.5%]), the late phenotype with onset at age 2 years or older (n = 50; 4.8%), and the never/infrequent phenotype (n = 825; 79.5%), defined as children with no atopic [...] atopic dermatitis. Children with both parents with history of allergies were 5 times more at risk to develop atopic dermatitis with an early-persistent phenotype compared with children with parents with no history
Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate... (Publications)
non-inferior to albendazole plus oxantel pamoate (ERRs 99.5% [95% CI 99.2-99.7] vs 96.0% [93.9-97.4]; difference 3.52 percentage points [2.05-5.65]). Likewise, tribendimidine plus oxantel pamoate was n [...] non-inferior to albendazole plus oxantel pamoate (ERRs 96.5% [95% CI 94.9 to 97.6] vs 96.0% [93.9 to 97.4]; difference 0.48 percentage points [-1.61 to 2.88]). 3 h after treatment, headache (n=50 [8%])