Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
amodiaquine and desethylamodiaquine reached 50% of adult maturation at 2.8 (95% CI: 1.5 - 3.7) and 3.9 (95% CI: 2.6 - 5.3) months after birth, assuming a baby born at term. Bioavailability was 22.4% (15.6
Physical activity and dual disease burden among South African primary schoolchildren from disadvantaged neighbourhoods (Publications)
VD phenotype burden in South African schoolchildren. 801 children (402 boys, 399 girls; mean age 9.5years) from eight schools from disadvantaged neighbourhoods were included. Data assessment took place [...] (physically active on 6-7days/week for at least 60min), who were active, but below recommended standards (2-5 physically active days/week), or who were insufficiently active on almost all days (0-1 physically active
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study (Publications)
ator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males;
A genome-wide association study on medulloblastoma (Publications)
associated with increased medulloblastoma risk (p < 1 x 10(-5)), but none were statistically significant after adjusting for multiple testing (p < 5 x 10(-8)). Thirteen of these variants were genotyped, whereas
Trends and inequalities in cardiovascular disease mortality across 7932 English electoral wards, 1982-2006: Bayesian spatial analysis (Publications)
since the 1980s, but there are few data on small-area trends. We estimated CVD mortality by ward in 5-year intervals between 1982 and 2006, and examined trends in relation to starting mortality, region [...] death rates using a Bayesian spatial technique for all 7932 English electoral wards in consecutive 5-year intervals between 1982 and 2006, separately for men and women aged 30-64 years and > /=65 years
How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis - designing a prospective... (Publications)
d.) measures for HRQOL and adherence and to generate an endpoint model. Two generic (SF-12 and EQ-5D-5L), one disease-specific (St. George's Respiratory Questionnaire) and one condition-specific (Hospital
Standard genotyping overestimates transmission of <em>Mycobacterium tuberculosis</em> among immigrants in a low incidence country (Publications)
found weak evidence for an association between birth origin and transmission (aOR 2.2, 95% CI: 0.9-5.5, comparing Swiss-born patients to others). In conclusion, standard genotyping overestimated recent
Brucellosis and bovine tuberculosis prevalence in livestock from pastoralist communities adjacent to Awash National Park, Ethiopia (Publications)
enzyme linked immunoassay for brucellosis, 4.8% (95%CI: 1.2-17.1%) of cattle and 22.8% (95%CI: 5.98-29.5%) of goats were reactors. Highest individual prevalence of both diseases was found in Afar settlements
Prevalence of impaired glucose metabolism and potential predictors: a rapid appraisal among >/= 45 year old residents of southern Tajikistan (Publications)
participants were diagnosed as diabetic, 5.1% had impaired glucose tolerance and 4.3% impaired fasting glucose. An elevated body mass index > /= 25 was observed in 61.5% of the cohort and an elevated blood
Parasitic infections, anemia and malnutrition among rural settled and mobile pastoralist mothers and their children in Chad (Publications)
women and 18% (CI 13-23) in children. Malaria prevalence was low among women (1%, CI 0.5-2) and children (3% CI 2-5). No significant difference was observed in the prevalence of parasitic infection between