Feeding and survival of the malaria vector Anopheles gambiae on plants growing in Kenya (Publications)
(Ricinus communis L.) had the longest survival times (mean and median survival time of 6.99 +/- 0.23 and 5.67 +/- 0.17 days, respectively), comparable to mosquitoes given 6% glucose (mean and median survival [...] containing a range of local plants, but no host for blood, and allowed to feed ad libitum: 6.7 +/- 0.5% (11/64) of those recaptured were found to contain detectable fructose (all females). Common plants
Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines (Publications)
synthesis, and in vitro and in vivo antimalarial evaluations of certain ester-modified neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline) derivatives. The modifications were carried out by introducing ester groups
Environmental tobacco smoke exposure and diabetes in adult never-smokers (Publications)
participants' study area as a random effect. RESULTS: The prevalence of DM and ETS in the sample was 5.5% and 47% respectively. There were 2779 never-smokers with 4% diabetes prevalence. Exposure to ETS increased
Parasitic infections, anemia and malnutrition among rural settled and mobile pastoralist mothers and their children in Chad (Publications)
women and 18% (CI 13-23) in children. Malaria prevalence was low among women (1%, CI 0.5-2) and children (3% CI 2-5). No significant difference was observed in the prevalence of parasitic infection between
The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease (Publications)
assessment of activity and extent of disease. METHODS: Twenty-six consecutive patients (21 females, 5 males; median age - years, range 17-86 years) with giant cell arteritis or Takayasu's arteritis were [...] Follow-up scans were performed in four patients. Twenty-six age- and gender-matched controls (21 females, 5 males; median age 71 years, range 17-86 years) were included. The severity of large-vessel [(18)F]FDG
What defines airflow obstruction in asthma? (Publications)
the framework of the European Community Respiratory Health Survey. In males, the 0.70 ratio showed 76.5% sensitivity and 100.0% specificity, the 0.75 ratio 100.0% sensitivity and 92.4% specificity, and the [...] specificity. In females, the 0.70 ratio showed 57.3% sensitivity and 100.0% specificity, the 0.75 ratio 91.5% sensitivity and 95.9% specificity, and the 0.80 ratio 100.0% sensitivity but 72.9% specificity. The
Use and misuse of a discount voucher scheme as a subsidy for insecticide-treated nets for malaria control in southern Tanzania (Publications)
been used in two rural districts of southern Tanzania as a way to target subsidies to children under 5 years and pregnant women. We assessed appropriate use and misuse of discount vouchers through a follow-up [...] Moreover, 94% of the ITNs bought with vouchers were used by those intended, women and children under 5 years. However, up to 48% (50/104) of the vouchers had been misused at the clinics that issued them
Development and validation of an enantioselective LM-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in... (Publications)
and concentrated on a C-18 trapping column. The analytical range for each PZQ enantiomer was 0.01-2.5µg/mL, and 0.1-25µg/mL for the metabolite. The method met the requirements regarding precision (±15% [...] pharmacokinetic studies. Moreover, the enantioselective separation was achieved with a run time of 11.5min and a simple sample processing method.
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
amodiaquine and desethylamodiaquine reached 50% of adult maturation at 2.8 (95% CI: 1.5 - 3.7) and 3.9 (95% CI: 2.6 - 5.3) months after birth, assuming a baby born at term. Bioavailability was 22.4% (15.6
Whole genome sequencing for drug resistance profile prediction in<em> Mycobacterium tuberculosis</em> (Publications)
73-99 % of cases, depending on the drug. Our data suggests that the established critical concentration (5 mg/L) for ethambutol resistance (MGIT 960 system) is too high and may misclassify strains as susceptible [...] resistance mechanisms. The overall sensitivity and specificity of whole genome-based DST were 86.8 % and 94.5 %, respectively.Despite some limitations, whole genome sequencing has the potential to infer resistance
