Medium-ring keto bislactams with antischistosomal activity (Publications)
cytotoxicities with IC(50s) ranging from 52 to > 390 μM. We identified two compounds with IC(50) values < 5 μM against ex vivoSchistosoma mansoni (S. mansoni).
Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, <em>Actinoallomurus fulvus</em> MK10-036 (Publications)
Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute
Effectiveness of four different interventions against <em>Schistosoma haematobium</em> in a seasonal transmission setting of Côte d'Ivoire: a cluster... (Publications)
compared to the standard treatment arm (0.6% vs 7.5%; odds ratio [OR] = 0.07, 95% confidence interval [CI] = .02 to .24). The prevalence in arms 2 and 4 was about 3.5%, which was not statistically significantly
Gynaecologic and breast cancers in women living with HIV in South Africa: A record linkage study (Publications)
gynaecologic cancer with patient- and municipal-level characteristics. From 3 447 908 women and 10.5 million years of follow-up, we identified 11 384 incident and 7612 prevalent gynaecologic and breast [...] [CI]: 106-110), with the highest incidence observed for cervical cancer (70/1 00 000 pyears; 95% CI: 68.5-71.7). Low CD4 cell counts and high HIV RNA viral loads increased the risk of cervical and other HPV-related
Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men (Publications)
46+/-7 years) who underwent the Trier Social Stress Test (combination of a 3-min preparation, 5-min speech, and 5-min mental arithmetic) three times with an interval of 1 week. Plasma IL-6 and free salivary
The influence of zinc supplementation on morbidity due to <em>Plasmodium falciparum</em>: a randomized trial in preschool children in Papua New Guinea (Publications)
parasites/microl with axial temperature > or = 37.5 degreesC or reported fever. Episodes accompanied by any parasitemia were also reduced by 38% (95% CI 5-60, P = 0.028), and episodes with parasitemia >
Prévalence, diversité antigénique et multiplicité d'infections de <em>Plasmodium falciparum</em> en milieu scolaire au centre de la Côte... (Publications)
light microscopy and polymerase chain reaction (PCR). A total of 424 schoolchildren ranging in age from 5 to 15 years underwent diagnostic testing using both light microscopy of blood smears and PCR. Multiplicity [...] the restriction fragment of the gene encoding the merozoite surface protein-2 (msp2) showed that 86.5% of cases involved multiple infection with a geometric mean of 3.87 genotypes per positive child. There
Air pollution and childhood leukaemia: a nationwide case-control study in Italy (Publications)
length of main roads within 100 m) and estimates of pollutants concentrations (particulate matter -PM2.5 and PM10- and gases -NO2 and O3-) from national dispersion model and land use regression models. The [...] controls lived along busy roads, and the mean annual PM10 levels were 33.3 (SD=6.3) and 33.4 µg/m3 (SD=6.5), respectively. No association was found, and all ORs, independent of the method of assessment and the
Mental health litaracy and the experience of depression in a community sample of gay men (Publications)
greater susceptibility among gay men, yet men with MDD reported problems with love/relationship (32.5%) and work (28.9%) as the most common perceived causes of recent depression, and problems with love [...] such as a close friend (91.6%), relaxation exercises or meditation (84.4%), and physical activity (83.5%) as being helpful for the depression vignette. LIMITATIONS: No probes used for open questions, and
Health impact assessment of transport policies in Rotterdam: decrease of total traffic and increase of electric car use (Publications)
kilometers and a share of 50% electric-powered private vehicle kilometers) on particulate matter (PM2.5), elemental carbon (EC) and noise (engine noise and tyre noise) were assessed using Years of Life Lost [...] have marginal effects on air pollution, because already implemented traffic policies will reduce PM2.5 and EC by around 40% and 60% respectively, from 2010 to 2020. DISCUSSION: The evaluation of planned