Molecular characterization, toxin detection and resistance testing of human clinical <em>Clostridium difficile </em>isolates from Lebanon (Publications)
testing. Ribotype 014 (RT014, 16.8%) predominated, followed by RT002 (9.3%), RT106 (8.4%) and RT070 (6.5%). Binary toxin gene-positive isolates (RT023, RT078 and RT126) were rarely detected and RT027 was absent [...] small proportion of strains displayed resistance against moxifloxacin, rifampicin, and clarithromycin (5.6%, 1.9%, and 2.8%), respectively. The data indicate that the genetic strain composition of Lebanese
Oral fexinidazole for late-stage African <em>Trypanosoma brucei gambiense </em>trypanosomiasis: a pivotal multicentre, randomised, non-inferiority... (Publications)
Therefore, we aimed to assess the safety and efficacy of an oral regimen of fexinidazole (a 2-substituted 5-nitroimidazole with proven trypanocidal activity) versus nifurtimox eflornithine combination therapy [...] statisticians were masked to treatment. Oral fexinidazole was given once a day (days 1-4: 1800 mg, days 5-10: 1200 mg). Oral nifurtimox was given three times a day (days 1-10: 15 mg/kg per day) with eflornithine
Global investment targets for malaria control and elimination between 2016 and 2030 (Publications)
Results: Annual investments of $6.4 billion (95% uncertainty interval (UI $4.5-$9.0 billion)) by 2020, $7.7 billion (95% UI $5.4-$10.9 billion) by 2025 and $8.7 billion (95% UI $6.0-$12.3 billion) by 2030
Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study (Publications)
sales and ethnicity, we found associations between cardiovascular mortality and PM2.5 copper with interdecile range (IDR 2.6-5.7 ng/m(3)) and IDR relative risk (RR) 1.005 (95%CI 1.001 to 1.009) and between
Animal-assisted therapy for patients in a minimally conscious state: a randomized two treatment multi-period crossover trial (Publications)
CI: 0.01 to 0.22, p = 0.038). AAT led to significantly higher LF (b = 5.82, 95% CI: 0.55 to 11.08, p = 0.031) and lower HF (b = -5.80, 95% CI: -11.06 to -0.57, p = 0.030), while heart rate, SDNN, RMSSD
Interventional cardiac catheterization predictors at Al-Arabi Heart Center in Palestine in 2017 (Publications)
tested negative for troponin on presentation. Multivariate logistic regression showed Troponin (RR = 4.5), Age (RR = 1.0), Female gender (RR = 0.4) previous catheterization (RR = 2.0), and existence of diabetes [...] for an interventional cardiac catheterization was significant only in case of ST-Elevation (RR = 1.5), and T wave inversion (RR = 1.6). CK-MB, Hypertension and ECG with ST-depression were not significant
The role of extreme temperature in cause-specific acute cardiovascular mortality in Switzerland: a case-crossover study (Publications)
daily Tmean (24 degrees C) versus optimum temperature at 20 degrees C) and cold (OR = 1.15 [0.95-1.39], 5th percentile of daily Tmean (-3 degrees C) versus optimum temperature at 20 degrees C). Heat-related [...] with lower socio-economic position and education are at higher risk for heat-related mortality. PM2.5 increased the risk of heat-related mortality for heart failure, but not all-cause cardiovascular mortality
A longitudinal study of cattle productivity in intensive dairy farms in central Ethiopia (Publications)
recorded in a herd-book. Whereas, half the farms saw their animals increase in number over the 3 years, 37.5% (mainly large farms) saw their herd size decrease. Offtakes accounted for 76.6% of all animal exits [...] mortality was observed in young stock (13.9%). Overall, diseases were the leading cause for death (57.5%). The majority of calves (69%) that died, did so within the first week of life. Mean calving interval
Viral suppression after transition from nonnucleoside reverse transcriptase inhibitor- to dolutegravir-based antiretroviral therapy: a prospective... (Publications)
was 47 years [interquartile range (IQR): 38-56], and median (IQR) time since ART initiation was 5.9 (3.5-9.0) years. Among those with complete VL data, the rate of viral suppression to < 100 copies/mL
Child hand contamination is associated with subsequent pediatric diarrhea in rural Democratic Republic of the Congo (REDUCE Program) (Publications)
enrolment and analysed for Escherichia coli. Caregiver reports of diarrhoea were obtained from children < 5 years at a 6-month follow-up. RESULTS: E.coli was detected in 73% of child and caregiver hand-rinse [...] observed putting in their mouths, 74% of stored water samples, and 40% of source water samples. Children < 5 years with E. coli on their hands had significantly higher odds of diarrhoea at the 6-month follow-up