Antibodies elicited by a virosomally formulated <em>Plasmodium falciparum</em> serine repeat antigen-5 derived peptide detect the processed 47kDa... (Publications)
Serine repeat antigen-5 (SERA5) is a candidate antigen for inclusion into a malaria subunit vaccine. During merozoite release and reinvasion the 120kDa SERA5 precursor protein (P120) is processed, and [...] 57-94 of SERA5 bound to both P120 and to P47. Western blotting analysis proved for the first time the presence of SERA5 P47 in sporozoites. In immunofluorescence assays, the mAbs stained SERA5 in all its [...] conjugates, incorporating amino acid sequence stretches from the N-terminus of...
Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives (Publications)
Three derivatives of N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino (1), a compound which exhibits significant activity against Trypanosoma cruzi and Plasmodium falciparum but with cytotoxicity
Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)
has not been thoroughly investigated in leishmania and trypanosomes. Work has previously shown that 5-benzyl-2,4-diaminopyrimidines are selective inhibitors of the leishmanial and trypanosome enzymes. Modelling [...] alkyl/aryl substitution on the 6-position of the pyrimidine ring should increase enzyme activity of 5-benzyl-2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase
The association of LUR modeled PM2.5 elemental composition with personal exposure (Publications)
predicting personal exposures. In this study, the association of LUR modeled concentrations of PM2.5 components with measured personal concentrations was determined. The elements of interest were copper [...] sites were selected in each city (15 participants per city). Outdoor, indoor and personal 96-hour PM2.5 samples were collected by the participants over periods of two weeks in three different seasons (winter [...] with measured personal Cu exposure. After excluding observations with an...