Respiratory health in cleaners in northern Europe: is susceptibility established in early life? (Publications)
RESULTS: Among 2138 ever-cleaners the risks of wheeze (OR 1.4, 95% CI 1.3-1.6), adult-onset asthma (1.5 [1.2-1.8]) and self-reported COPD (1.7 [1.3-2.2]) were increased. The risk increased with years in [...] years was significantly stronger for those with early life disadvantage than in those without (1.8 [1.5-2.3] vs. 1.3 [0.96-1.8]; pinteraction 0.035). CONCLUSIONS: Occupational cleaners had increased risk
Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD (Publications)
loci (CFH, CFB, HTRA1, AMRS2, and VEGFA) as well as not yet reported AMD-associated genes (KDR, LRP5, and FZD4) were determined, and their frequencies were compared. Results. Of the 309 eyes included in [...] loci CFH, HTRA1, and AMRS2 were confirmed, and a risk-conferring polymorphism in one new locus, LRP5, was identified. Conclusions. Genetic predisposition may account for the variability in response to
A geographic information and remote sensing based model for prediction of <em>Oncomelania hupensis </em>habitats<em> </em>in the Poyang Lake area,... (Publications)
Schistosoma japonicum, in the Poyang Lake area, China. In a first step, two multi-temporal Landsat TM 5 satellite images, one from the wet and the second from the dry season, were visually classified into [...] temperature measurements in April and August yielded a range of 22.8-24.2 degrees C, and pH values of 6.0-8.5 were derived from existing records. Both climatic features represent suitable breeding conditions for
Combination chemotherapy against <em>Clonorchis sinensis</em>: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in the... (Publications)
artesunate, for example, reduced worm burden by 50% and 95%, respectively. Artemether and OZ78 (12.5-50 mg/kg) showed dose-dependent killing, but no significant drug interactions when given with 150 mg/kg [...] praziquantel, suggesting independent additive effects. In contrast, artesunate and tribendimidine (12.5-50 mg/kg) showed synergistic interactions with 150 mg/kg praziquantel. When low doses of 3.1 and 6.25
An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages (Publications)
years) were analysed. RESULTS: The overall prevalence was 11.8% (95% CI 11.3 to 12.3) for stage 0, 2.5% (95% CI 2.2 to 2.7) for stage I, and 1.1% (95% CI 1.0 to 1.3) for stages II-III. Moderate to heavy [...] stage 0 (relative risk ratio (RRR)=4.15; 95% CI 3.55 to 4.84) and stages I+ (RRR=4.09; 95% CI 3.17 to 5.26), while subjects with stages I+ COPD had a higher likelihood of giving up smoking (RRR=1.39; 95%
Predicting outcomes in critically ill patients with acute kidney injury undergoing intermittent hemodialysis - A retrospective cohort analysis (Publications)
recovery. Results: Totally, we included 39 patients with a mean APACHE II score of 20.1 (SD 7.5) who had an average of 5.1 +/- 4.8 hemodialysis sessions. All-cause mortality was 35.9% (14/39 patients). In mu
Allergic disease and sensitization in Steiner school children (Publications)
Cross-sectional multicenter study including 6630 children age 5 to 13 years (4606 from Steiner schools and 2024 from reference schools) in 5 European countries. RESULTS: The prevalence of several studied
Field efficacy of thermally expelled or live potted repellent plants against African malaria vectors in western Kenya (Publications)
significant repellency against Anopheles gambiae sensu lato Giles (Diptera: Culicidae) (81.5%An. arabiensis Patton and 18.5%An. gambiae sensu stricto Giles), the main vectors of malaria in Africa, with the highest
Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital (Publications)
younger than 5 years admitted with severe malaria. RESULTS: Seven thousand and forty-three children were admitted with a diagnosis of malaria. 25.2% fulfilled the criteria for severe malaria. 5.4% of the
Monitoring chloroquine resistance using <em>Plasmodium falciparum</em> parasites isolated from wild mosquitoes in Tanzania (Publications)
isolates were of single infection (71%), and the prevalence of mutant alleles of Pfcrt76 decreased from 64.5% in 2002 to 16% in 2004; likewise, mutant Pfmdr1-86 alleles decreased from 46.6% to 2.7%. Overall, there [...] isolates with wild-type alleles increased significantly from < 20% in 2002 to 67.6% for Pfcrt76 and 83.5% for Pfmdr1-86 in 2004. This observation suggest a biologic trend of decrease of CQ mutants and a subsequent