Bayesian spatio-temporal modeling of mortality in relation to malaria incidence in western Kenya (Publications)
positive association with malaria-specific mortality in young children (HR = 9.48; 5.11-37.94), however, in older children (5-14 years), it was associated with a reduction in malaria specific mortality (HR
Can school-based distribution be used to maintain coverage of long-lasting insecticide treated bed nets: evidence from a large scale programme in... (Publications)
and distributed one LLIN to each enrolled child attending schools in primary grades (standards) 1, 3, 5 and 7, and secondary grades (forms) 2 and 4 in 2013 and again with slightly modified eligibility criteria [...] , ownership of at least one LLIN had dropped significantly in the control area to 65.4% (95% CI 59.5-71.0) in 2015 (P < 0.001), while coverage in the intervention area was maintained at 79.3% (95% CI 75
Efficacy of moxidectin versus ivermectin against <em>Strongyloides stercoralis</em> infections: a randomized controlled non-inferiority trial (Publications)
compared to 95.2% (59/62) for ivermectin. Difference between CRs were estimated as -1.5%-pts (95% CI: -9.6 - 6.5), thus the lower limit of the CI exceeds the non-inferiority margin of 7%-pts. No side
Combination chemotherapy against <em>Clonorchis sinensis</em>: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in the... (Publications)
artesunate, for example, reduced worm burden by 50% and 95%, respectively. Artemether and OZ78 (12.5-50 mg/kg) showed dose-dependent killing, but no significant drug interactions when given with 150 mg/kg [...] praziquantel, suggesting independent additive effects. In contrast, artesunate and tribendimidine (12.5-50 mg/kg) showed synergistic interactions with 150 mg/kg praziquantel. When low doses of 3.1 and 6.25
Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD (Publications)
loci (CFH, CFB, HTRA1, AMRS2, and VEGFA) as well as not yet reported AMD-associated genes (KDR, LRP5, and FZD4) were determined, and their frequencies were compared. Results. Of the 309 eyes included in [...] loci CFH, HTRA1, and AMRS2 were confirmed, and a risk-conferring polymorphism in one new locus, LRP5, was identified. Conclusions. Genetic predisposition may account for the variability in response to
Health impact assessment of transport policies in Rotterdam: decrease of total traffic and increase of electric car use (Publications)
kilometers and a share of 50% electric-powered private vehicle kilometers) on particulate matter (PM2.5), elemental carbon (EC) and noise (engine noise and tyre noise) were assessed using Years of Life Lost [...] have marginal effects on air pollution, because already implemented traffic policies will reduce PM2.5 and EC by around 40% and 60% respectively, from 2010 to 2020. DISCUSSION: The evaluation of planned
Oral fexinidazole for late-stage African <em>Trypanosoma brucei gambiense </em>trypanosomiasis: a pivotal multicentre, randomised, non-inferiority... (Publications)
Therefore, we aimed to assess the safety and efficacy of an oral regimen of fexinidazole (a 2-substituted 5-nitroimidazole with proven trypanocidal activity) versus nifurtimox eflornithine combination therapy [...] statisticians were masked to treatment. Oral fexinidazole was given once a day (days 1-4: 1800 mg, days 5-10: 1200 mg). Oral nifurtimox was given three times a day (days 1-10: 15 mg/kg per day) with eflornithine
Molecular characterization, toxin detection and resistance testing of human clinical <em>Clostridium difficile </em>isolates from Lebanon (Publications)
testing. Ribotype 014 (RT014, 16.8%) predominated, followed by RT002 (9.3%), RT106 (8.4%) and RT070 (6.5%). Binary toxin gene-positive isolates (RT023, RT078 and RT126) were rarely detected and RT027 was absent [...] small proportion of strains displayed resistance against moxifloxacin, rifampicin, and clarithromycin (5.6%, 1.9%, and 2.8%), respectively. The data indicate that the genetic strain composition of Lebanese
Global investment targets for malaria control and elimination between 2016 and 2030 (Publications)
Results: Annual investments of $6.4 billion (95% uncertainty interval (UI $4.5-$9.0 billion)) by 2020, $7.7 billion (95% UI $5.4-$10.9 billion) by 2025 and $8.7 billion (95% UI $6.0-$12.3 billion) by 2030
Transient hyperglycemia in patients with tuberculosis in Tanzania: implications for diabetes screening algorithms (Publications)
DM prevalence was significantly higher among TB patients (N=539; FCG> 7mmol/L:4.5%, 2-hCG> 11mmol/L:6.8% and HbA1c> 6.5%:9.3%) compared to controls (N=496; 1.2%, 3.1% and 2.2%). Association between hy