Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study (Publications)
status, and several other potential confounders or intermediates.Results: Exposure contrasts between the 5th and 95th percentiles for NO2 (25 µg/m3), traffic intensity in the nearest street (15,000 vehicles/day) [...] traffic load within 100 m (7,200,000 vehicle-m/day) were associated with differences of 0.56% (95% CI: -1.5, 2.6%), 2.32% (95% CI: 0.48, 4.17%), and 1.91% (95% CI: -0.24, 4.06) percent difference in IMT, respectively
Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008 (Publications)
malaria in-patient cases by 78% (48-90%), and parasitologically-confirmed malaria out-patient cases by 99.5% (92-99.9%). Anaemia in-patient cases decreased by 87% (57-96%); anaemia deaths and out-patient cases [...] effective malaria interventions reduced malaria-related burden at health facilities by over 75% within 5 years. In high-malaria settings, intensified malaria control can substantially contribute to reaching
The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
Switzerland and in Tanzania. P27A antigen (10 or 50mug), adjuvanted with Alhydrogel(R) or GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed
A factorial cluster-randomised controlled trial combining home-environmental and early child development interventions to improve child health and... (Publications)
indoor kitchen 24-h air concentration levels of carbon monoxide (CO) and fine particulate matter (PM2.5) and CO for personal exposure. RESULTS: We recruited and randomised 317 children from 40 community-clusters [...] coliforms and the occurrence of E.coli was evenly distributed between arms. The mean levels of kitchen PM2.5 and CO concentrations were 213 mug/m(3) and 4.8 ppm, respectively. CONCLUSIONS: The trial arms are balanced
Outpatient treatment of imported uncomplicated <em>Plasmodium falciparum</em> malaria: results from a survey among TropNet and GeoSentinel experts for... (Publications)
semi-immunity. The threshold parasitaemia for outpatient treatment varied from 0.1% to 5% with a median of 2%. A median of 0.5% of outpatients were admitted during follow-up. During the last 10 years, 33 com
Transportation noise impairs cardiovascular function without altering sleep: the importance of autonomic arousals (Publications)
scenarios compared to the quiet ambient scenario played back during the baseline and recovery nights (F5,117 = 10.2, p < 0.001). Nocturnal transportation noise did not significantly impact polysomnographically [...] a result related to increased cumulative duration of autonomic arousals during the noise nights (F5,106 = 3.4, p < 0.001; correlation: rpearson = 0.64, p = 0.006). Conclusion: Under controlled laboratory
Association between transportation noise and cardio-metabolic diseases: an update of the WHO meta-analysis (Publications)
Thirteen studies were included in the IHD meta-analysis, contributing 13 risk estimates for road traffic, 5 for aircraft and 3 for railway noise exposure. Only the result for road traffic noise reached statistical [...] significance (1.02 [1.00-1.04] per 10 dB Lden). For diabetes, 6 studies were included, contributing 5 risk estimates for road traffic, 3 for aircraft and 2 for railway noise exposure. Again, only the road
Health services for Buruli ulcer control: lessons from a field study in Ghana (Publications)
introduced in the course of the programme, was highest in the last year (35.4% in the first, 23.5% in the second and 42.5% in the third year). Early antibiotic treatment prevented recurrences which was consistent
Quinolone amides as anti-trypanosomal lead compounds with in vivo activity (Publications)
synthesized compounds GHQ242 and GHQ243 were characterized by an elimination half-life ranging from 1.5 to 3.5 hours after i.p. administration (4 mice/compound), moderate to strong human serum albumin binding
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
group of 4577 RTS,S/AS01-vaccinated participants and 2335 control-vaccinated participants who were 5 to 17 months of age, the 1-year cumulative vaccine efficacy was 50.3% (95% confidence interval [CI] [...] differential allele-specific vaccine efficacy. Conclusions These results suggest that among children 5 to 17 months of age, the RTS,S vaccine has greater activity against malaria parasites with the matched