Pastoralism and resulting challenges for national parks in Afar, Ethiopia (Publications)
pastoral encroachment into parks. Among the pastoralists, 74.7% migrated with their livestock for a mean 3.5 months per year, during which time, 90% of respondents reported contact with other livestock herds, [...] the main threat caused by the presence of pastoralists, whereas diseases were only mentioned by 15.5%. Overall, park staff showed poor disease knowledge. They reported poor disease surveillance and no
Estimating prevalence and infection intensity of soil-transmitted helminths using quantitative polymerase chain reaction and Kato-Katz in school-age... (Publications)
112 (58.6%) became positive. Similar prevalence for Ascaris lumbricoides (37.5% versus 34.6%) and Trichuris trichiura (6.5% versus 6.1%) were found by qPCR and Kato-Katz, respectively, while qPCR detected
Genetic characterization and population structure of drug-resistant <em>Mycobacterium tuberculosis</em> isolated from Brazilian patients using... (Publications)
of 22.5%. We detected twenty novel mutations in three resistance genes, and six of these were observed in eight phenotypically resistant isolates. A cluster analysis of 170 isolates showed that 43.5% of
The number of comorbidities as an important cofactor to ASA class in predicting postoperative outcome: an international multicentre cohort study (Publications)
enrolled patients, the mean number of comorbidities significantly increased from 1.5 in ASA I (95% CI, 1.1-1.9) to 10.5 in ASA IV (95% CI, 8.3-12.7) patients. Furthermore, independent of ASA class, pos
Urinary pesticide mixture patterns and exposure determinants in the adult population from the Netherlands and Switzerland: application of a suspect... (Publications)
samples. The most frequent combination of biomarkers (acetamiprid-flonicamid) was detected in 22 (5.5%) samples. Regression models revealed an inverse association between high organic vegetable and fruit
Safety and protective efficacy of PfSPZ vaccine administered to HIV negative and positive Tanzanian adults (Publications)
HIV+ Tanzanians (HIV viral load < 40 copies/mL, CD4 counts > 500 cells/µL). Participants received 5 doses of PfSPZ Vaccine or normal saline over 28 days followed by controlled human malaria infection [...] adverse events in the 9 HIV- and 12 HIV+ participants. After CHMI, 6/6 normal saline (NS) controls, 1/5 HIV- vaccinees and 4/4 HIV+ vaccinees were Pf positive by qPCR. Post-immunization, anti-PfCSP (isotype
Human African trypanosomiasis (Publications)
very advanced cases. The treatment-related mortality rate consequently dropped from 5% with melarsoprol to around 0.5%. A single-dose oral treatment, acoziborole, has completed Phase III trials and may
Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and... (Publications)
We calculated the equivalent annual cost of rectal artesunate implementation per child younger than 5 years at risk of severe malaria, from a health system perspective, separating neglected routine health [...] ng the neglected, routine health system components accounted for the majority of these costs at 71.5%, 65.4%, and 76.4% of per-child costs, respectively. Incremental rectal artesunate costs accounted for
Signatures of transmission in within-host <em>Mycobacterium tuberculosis </em>complex variation: a retrospective genomic epidemiology study (Publications)
across studies: mean 168·6 minority variants (95% CI 151·4-185·9) for the Colangeli et al dataset, 5·8 (1·5-10·2) for Guthrie et al (p
Health system support among patients with ME/CFS in Switzerland (Publications)
disease knowledge among health professionals in Switzerland led 13.5% of the patients to travel abroad to seek a diagnosis. Most patients (90.5%) were told at least once that their symptoms were psychosomatic