Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
with promising activity: N(6)-benzyl-5'-N-phenylcarboxamidoadenosine with an IC(50) value of 0.91muM against Trypanosoma brucei rhodesiense and N(6)-diphenylethyl-5'-phenylcarboxamidoadenosine with an IC(50) [...] speed up the process of lead finding and we pursued the solid-phase synthesis of di- and trisubstituted 5'-carboxamidoadenosine derivatives by using a safety-catch approach. While efforts with Kenner's sulfonamide
Studies on <em>Dipetalonema viteae</em> (Filarioidea). 5. Ultrastructural aspects of the antibody-dependent cell-mediated destruction of microfilariae (Publications)
The antibody-dependent cell-mediated destruction of Dipetalonema viteae microfilariae was followed by electron microscopy both in vitro and within micropore chambers in vivo. There was a correlation b
Genomic distribution and functional characterisation of two distinct and conserved <em>Plasmodium falciparum</em> var gene 5' flanking sequences (Publications)
conserved types of 5' upstream regions (var17-type and 5B1-type) of var genes, and suggest that most subtelomeric var genes are flanked by a var17-type 5' upstream sequence. In contrast, 5B1-type 5' upstream are [...] that var genes flanked by either type of 5' upstream sequence are transcribed in in vitro cultured trophozoite stage parasites. In addition, we have shown that the 5' flanking sequences of four different
Source apportionment of ambient PM2.5 at five spanish centres of the european community respiratory health survey (ECRHS II) (Publications)
clearly observed in PM2.5. Multi-linear regression analysis (MLRA) was applied to the data, showing that traffic was the main source of PM2.5 at the five sites (39-53% of PM2.5, 5.1-12.0 mgm [...] particulate matter (PM2.5) was sampled at 5 Spanish locations during the European Community Respiratory Health Survey II (ECRHS II). In an attempt to identify and quantify PM2.5 sources, source contribution [...] analysis (PCA) was performed on five datasets containing elemental composition of PM2.5...
Source apportionment of PM2.5 and selected hazardous air pollutants in Seattle (Publications)
with the PM(2.5) data, the models identified that wood burning (24%-31%), secondary sulfate (20%-24%) and secondary nitrate (15%-20%) were the main contributors to PM(2.5). Using only PM(2.5) data, the model [...] of combining the speciated PM(2.5) and VOCs data in source apportionment analysis for identification of additional sources remain unclear. We analyzed the speciated PM(2.5) and VOCs data collected at the [...] constraint. When both PM(2.5) and VOCs data were used, one additional...
Land use regression models for crustal and traffic-related PM2.5 constituents in four areas of the SAPALDIA study (Publications)
particulate matter (PM2.5), but there is still limited knowledge regarding the causal relationship between specific sources of PM2.5 and such health effects. The spatial variability of PM2.5 constituents and [...] (SAPALDIA). Reflectance analysis and energy dispersive X-ray fluorescence (XRF) were performed on PM2.5 filter samples to estimate light absorbance and trace element concentrations, respectively. Three air
Antileukemic ancistrobenomine B and related 5,1′-coupled naphthylisoquinoline alkaloids from the Chinese liana <em>Ancistrocladus tectorius</em> (Publications)
predominance of 5,1'-coupled naphthylisoquinoline alkaloids. About 20 alkaloids of this coupling type have so far been discovered in this plant species. Here, we report on the isolation of four new 5,1'-linked [...] naphthylisoquinolines from the twigs and stems of A. tectorius. Two of them, the ancistrobenomines B (5) and C (6), belong to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion [...] from one single naphthalene-devoid 3-hydroxymethyleneisoquinoline from...
