Efficacy and safety of ascending dosages of albendazole against <em>Trichuris trichiura</em> in preschool-aged children, school-aged children and... (Publications)
PSAC was 27.8% (95% CI: 9.7%-53.5%) in the 600 mg albendazole treatment arm. The most efficacious arm for SAC was 600 mg of albendazole showing a CR of 25.6% (95% CI: 13.5%-41.2%), and for adults it was
Land use regression models for estimating individual NOx and NO2 exposures in a metropolis with a high density of traffic roads and population (Publications)
stepwise multiple regressions. The annual average concentrations of NOx and NO2 in Taipei were 72.4 +/- 22.5 and 48.9 +/- 12.2 mug/m(3), respectively, which were at the high end of all 36 European areas in the [...] were lengths of major roads within 25 m, 25-50 m, and 50-500 m, urban green areas within 300 m and 300-5,000 m, and semi-natural and forested areas within 500 m, with R(2)=0.81. The NO2 LUR model included
Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets (Publications)
malnourished. Mean (range) nevirapine C12h, Cmax and AUC12h of 6.0 (1.4, 16.9) mg/l, 10.0 (3.8, 22.5) mg/l and 94.4 (32.1, 232) mg/l per hour were higher than those reported in adults. Nevirapine C12h [...] lamivudine C12h, Cmax, AUC12h ( < 0.015 mg/l, 0.45 mg/l, 1.05 mg/l per hour and 0.09 mg/l, 1.33 mg/l, 5.42 mg/l per hour) were comparable to adults. There was no evidence of a difference in nevirapine AUC12h
Countdown to 2015: tracking donor assistance to maternal, newborn, and child health (Publications)
mortality and ODA per head, although at any given rate of mortality for children aged younger than 5 years or maternal mortality, there is significant variation in the amount of ODA per person received [...] If commitments are to be honoured, global aid flows will need to increase sharply during the next 5 years. The challenge will be to ensure a sufficient share of these new funds is channelled effectively
Comparative genomics of the anopheline glutathione s-transferase epsilon cluster (Publications)
analysis and protein modelling gave evidence for positive selection on codons of the catalytic site in GSTE5 albeit its origin seems to predate the introduction of chemical insecticides. Gene expression profiles [...] World Cellia subgenus, instead of a secondary loss. The modifications of the catalytic site within GSTE5 may represent adaptations to new habitats
Determinants of virological failure and antiretroviral drug resistance in Mozambique (Publications)
III/IV [OR = 2.10 (95% CI = 1.23-3.57), P = 0.003] and low ART adherence [OR = 2.69 (95% CI = 1.39-5.19), P = 0.003] were associated with virological failure. Longer time on ART [OR = 1.55 per additional [...] clinical and immunological outcomes, only achieved 29% sensitivity and misdiagnosed 1 out of every 4.5 subjects. CONCLUSIONS: Public health programmes in Mozambique should focus on early HIV diagnosis, early
Bridging the gap: how traditional healers interact with their patients. A comparative study in Cameroon (Publications)
except for age, where TH patients were on average 9 years younger (P < 0.05). Patients of TH travelled 2.5 times as far to their provider as did patients in the WP group (79 vs. 31 km; P < 0.05) and paid 12 [...] 12 times more for their treatment (123 vs. 10 Euros; P < 0.05). Consultations of TH were shorter (5.6 vs. 10.3 min, P < 0.01), had fewer utterances (100 vs. 166, P < 0.05) and the patient's share in the
Perceived illness drives participation in mass deworming campaigns in Laos (Publications)
(19/21). Most leaders (20/21) had a good knowledge on severe schistosomiasis though only a few of them (5/21) described its cause correctly. They knew little about the disease consequences of liver fluke (3/21) [...] fish (100%), frequent physical contacts with Mekong River water (76.0%) and low number of latrines (14.5%). In conclusion, MDA is widely accepted in affected communities. Avoiding severe schistosomiasis was
First insights into the phylogenetic diversity of <em>Mycobacterium tuberculosis</em> in Nepal (Publications)
(Euro-American lineage) with 41 (15.7%) isolates, and Lineage 1 (Indo-Oceanic lineage) with 30 isolates (11.5%). Based on spoligotyping, we found 45 different spoligotyping patterns that were previously described [...] confidence interval [95% CI] 1.42-4.67, p = 0.002), and any drug resistance (aOR 2.79; 95% CI 1.43-5.45; p = 0.002). We found no evidence for an association of Lineage 2 with age or BCG vaccination status
Toward measuring <em>Schistosoma</em> response to praziquantel treatment with appropriate descriptors of egg excretion (Publications)
reduction in their egg counts (ERR = 0). The 5th, 10th, and 25th centiles of the subjects treated for S. haematobium had individual ERRs of 0%, 49.3%, and 96.5%; the corresponding values for S. japonicum